AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10109497" target="_blank" >RIV/00216208:11310/10:10109497 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE

Popis výsledku v původním jazyce

Introduction:Changes in cell surface glycosylation accompanies diseases such as inflammation, rheumatoid arthritis, and malignant transformations. These changes are supposed to be monitored by carbohydrate receptors of lectin type on the surface of cellsof the immune system. However, the exact nature of these receptors orchestrating such reactions remains elusive. Methods: We used a panel of recombinant lectin-like receptors of killer lymphocytes, bioaffinity techniques, oligosaccharide arrays, and mass spectrometry to analyze the complete oligosaccharide profiles responsible for sensitivity of tumor cells for natural killing and apoptosis. Results: Highly branched N-linked oligosaccharides recognized by NKR-P1 and NKG2D receptors were linked to sensitivity to natural killing. On the other hand, clustered O-linked oligosaccharides cross-linking CD69 receptors were able to cause the apoptotic death of the activated killer lymphocytes. Conclusions: We were able to identify classes of su

Název v anglickém jazyce

AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE

Popis výsledku anglicky

Introduction:Changes in cell surface glycosylation accompanies diseases such as inflammation, rheumatoid arthritis, and malignant transformations. These changes are supposed to be monitored by carbohydrate receptors of lectin type on the surface of cellsof the immune system. However, the exact nature of these receptors orchestrating such reactions remains elusive. Methods: We used a panel of recombinant lectin-like receptors of killer lymphocytes, bioaffinity techniques, oligosaccharide arrays, and mass spectrometry to analyze the complete oligosaccharide profiles responsible for sensitivity of tumor cells for natural killing and apoptosis. Results: Highly branched N-linked oligosaccharides recognized by NKR-P1 and NKG2D receptors were linked to sensitivity to natural killing. On the other hand, clustered O-linked oligosaccharides cross-linking CD69 receptors were able to cause the apoptotic death of the activated killer lymphocytes. Conclusions: We were able to identify classes of su

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GD305%2F09%2FH008" target="_blank" >GD305/09/H008: Příprava, biotransformace a optimalizace látek s protinádorovými a antimikrobiálními účinky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 6th international conference on polysaccharides-glycoscience

ISBN

978-80-86238-78-4

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

5-8

Název nakladatele

Czech chemical society

Místo vydání

Novotného Lávka 5, Prague, CZECH REPUBLIC

Místo konání akce

Prague, CZECH REPUBLIC

Datum konání akce

29. 9. 2010

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000287421800001