Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10051856" target="_blank" >RIV/00216208:11310/11:10051856 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/11:00358984 RIV/00023001:_____/11:00002747 RIV/67985858:_____/11:00358984 RIV/68378041:_____/11:00358984

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c0jm01258k" target="_blank" >http://dx.doi.org/10.1039/c0jm01258k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c0jm01258k" target="_blank" >10.1039/c0jm01258k</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles

Popis výsledku v původním jazyce

The present study reveals the potential of magnetic nanoparticles based on the La0.75Sr0.25MnO3 perovskite manganite for MRI. Moreover, it describes the development of the dual imaging probe where the magnetic cores are combined with a fluorescent moietywhile the improved colloidal stability is achieved by a two-ply silica shell. At first, the magnetic cores of La0.75Sr0.25MnO3 are coated with a hybrid silica layer, comprising a covalently attached fluorescein moiety that is subsequently covered by a pure silica layer providing the enhanced stability. Viability tests show that the complete particles are suitable for biological studies and the internalization occurs in different cell types. Further experiments prove no fatal interference with the vitality. Relaxometric measurements confirm high spin-spin relaxivities and visualisation of in vitro labeled pancreatic islets by MRI is successfully tested.

Název v anglickém jazyce

Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles

Popis výsledku anglicky

The present study reveals the potential of magnetic nanoparticles based on the La0.75Sr0.25MnO3 perovskite manganite for MRI. Moreover, it describes the development of the dual imaging probe where the magnetic cores are combined with a fluorescent moietywhile the improved colloidal stability is achieved by a two-ply silica shell. At first, the magnetic cores of La0.75Sr0.25MnO3 are coated with a hybrid silica layer, comprising a covalently attached fluorescein moiety that is subsequently covered by a pure silica layer providing the enhanced stability. Viability tests show that the complete particles are suitable for biological studies and the internalization occurs in different cell types. Further experiments prove no fatal interference with the vitality. Relaxometric measurements confirm high spin-spin relaxivities and visualisation of in vitro labeled pancreatic islets by MRI is successfully tested.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BM - Fyzika pevných látek a magnetismus

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry

ISSN

0959-9428

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

157-164

Kód UT WoS článku

000285067300019

EID výsledku v databázi Scopus

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