Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105754" target="_blank" >RIV/00216208:11310/11:10105754 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/11:00364584 RIV/68378050:_____/11:00364584

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jez.b.21408" target="_blank" >http://dx.doi.org/10.1002/jez.b.21408</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jez.b.21408" target="_blank" >10.1002/jez.b.21408</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

Popis výsledku v původním jazyce

For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer-aided three-dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild-type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represente

Název v anglickém jazyce

Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

Popis výsledku anglicky

For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer-aided three-dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild-type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represente

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

ISSN

1552-5007

e-ISSN

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Svazek periodika

316B

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

347-358

Kód UT WoS článku

000291699400005

EID výsledku v databázi Scopus

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