Sequential Shh Expression in the Development of the Mouse Upper Functional Incisor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10145767" target="_blank" >RIV/00216208:11310/13:10145767 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/13:00397915

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jez.b.22522" target="_blank" >http://dx.doi.org/10.1002/jez.b.22522</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jez.b.22522" target="_blank" >10.1002/jez.b.22522</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sequential Shh Expression in the Development of the Mouse Upper Functional Incisor

Popis výsledku v původním jazyce

The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed avery detailed investigation of the development of the upper incisor in wild-type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer-aided three-dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5-13.5, there was a single Shh positive domain present in the anterior part of left orright upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expressi

Název v anglickém jazyce

Sequential Shh Expression in the Development of the Mouse Upper Functional Incisor

Popis výsledku anglicky

The mouse incisor is a frequently used model in studies of the molecular control of organ development. The appropriate interpretation of data on normogenesis is essential for understanding the data obtained in mutant mice. For this reason, we performed avery detailed investigation of the development of the upper incisor in wild-type mice from embryonic day (ED) 11.5 till 14.5. A combination of histology, whole mount in situ hybridization, computer-aided three-dimensional reconstructions, and fluorescent microscopy, has been used. Several sonic hedgehog (Shh) expression domains have been detected in the upper incisor region during early prenatal development. At ED11.5-13.5, there was a single Shh positive domain present in the anterior part of left orright upper jaw arches, corresponding to the epithelial thickening. More posteriorly, a new Shh expression domain appeared in the incisor bud in the developmentally more advanced ED13.5 embryos. At ED14.5, only this posterior Shh expressi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

ISSN

1552-5007

e-ISSN

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Svazek periodika

320

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

455-464

Kód UT WoS článku

000325473100006

EID výsledku v databázi Scopus

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