The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of gamma delta T lymphocytes in pigs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10105038" target="_blank" >RIV/00216208:11310/12:10105038 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/12:00379094

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.dci.2011.11.003" target="_blank" >http://dx.doi.org/10.1016/j.dci.2011.11.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dci.2011.11.003" target="_blank" >10.1016/j.dci.2011.11.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of gamma delta T lymphocytes in pigs

Popis výsledku v původním jazyce

The expression of selected molecules was chosen to study porcine gamma delta lymphocytes and their CD2/CD8 subsets in different lymphoid organs in vivo and in vitro. Results indicate that many gamma delta T cells can constitutively express CD25 and MHC-II and that the frequency of gamma delta T cells positive for CD25, CD11b, SWC1 and SWC7 can be increased by stimulation. A diversified TCRdelta repertoire was found inside CD25+, CD11b+, SWC1- and CD45RA- cells. Ontogenetic studies revealed various age and/or colonization dependency for expression of all studied molecules except of SWC7. Findings generally indicate that CD25 represent an activation molecule that probably marks a functionally distinct subsets, expression of CD11b is perhaps connected toearly functions of naive gamma delta T cells in the periphery, SWC1 is lineage specific marker, SWC7 may represent an activation molecule with intrinsic or transient expression, and the expression of CD45RA/RC most likely defines naive an

Název v anglickém jazyce

The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of gamma delta T lymphocytes in pigs

Popis výsledku anglicky

The expression of selected molecules was chosen to study porcine gamma delta lymphocytes and their CD2/CD8 subsets in different lymphoid organs in vivo and in vitro. Results indicate that many gamma delta T cells can constitutively express CD25 and MHC-II and that the frequency of gamma delta T cells positive for CD25, CD11b, SWC1 and SWC7 can be increased by stimulation. A diversified TCRdelta repertoire was found inside CD25+, CD11b+, SWC1- and CD45RA- cells. Ontogenetic studies revealed various age and/or colonization dependency for expression of all studied molecules except of SWC7. Findings generally indicate that CD25 represent an activation molecule that probably marks a functionally distinct subsets, expression of CD11b is perhaps connected toearly functions of naive gamma delta T cells in the periphery, SWC1 is lineage specific marker, SWC7 may represent an activation molecule with intrinsic or transient expression, and the expression of CD45RA/RC most likely defines naive an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F07%2F0087" target="_blank" >GA524/07/0087: Vývoj periferních gama delta T lymfocytů u prasat</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Developmental and Comparative Immunology

ISSN

0145-305X

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

728-740

Kód UT WoS článku

000302277700011

EID výsledku v databázi Scopus

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