Porcine gamma delta T Lymphocytes Can Be Categorized into Two Functionally and Developmentally Distinct Subsets according to Expression of CD2 and Level of TCR

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191803" target="_blank" >RIV/00216208:11310/13:10191803 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/13:00392730

Výsledek na webu

<a href="http://dx.doi.org/10.4049/jimmunol.1202890" target="_blank" >http://dx.doi.org/10.4049/jimmunol.1202890</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4049/jimmunol.1202890" target="_blank" >10.4049/jimmunol.1202890</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Porcine gamma delta T Lymphocytes Can Be Categorized into Two Functionally and Developmentally Distinct Subsets according to Expression of CD2 and Level of TCR

Popis výsledku v původním jazyce

Porcine gamma delta T cells have two levels of TCR gamma delta expression. Whereas TCR gamma delta(med) cells are mostly CD2(+)CD8(-) and CD2(+)CD8(+), TCR gamma delta(hi) cells are highly enriched for CD2(-)CD8(-). This distribution is independent of bacterial colonization and it is already established in the thymus prior to export of gamma delta cells to the periphery. Sorting and cultivation experiments revealed that CD2(-)CD8(-) gamma delta cells are unable to acquire CD2 and CD8, whereas CD2(+) subsets can gain or loose CD8. There is also differential susceptibility for proliferation between CD2(+) and CD2(-) gamma delta cells. Although CD2(-)CD8(-) almost do not proliferate, proliferation of CD2(+)CD8(-) and CD2(+)CD8(+) is substantial. Population of CD2(-) gamma delta cells is also absent in CD1(+) immature thymocytes. Additionally, subpopulations of CD2(+) and CD2(-) gamma delta cells in the thymus differ in expression of auxiliary surface molecules such as CD25, CD45RA/RC, and

Název v anglickém jazyce

Porcine gamma delta T Lymphocytes Can Be Categorized into Two Functionally and Developmentally Distinct Subsets according to Expression of CD2 and Level of TCR

Popis výsledku anglicky

Porcine gamma delta T cells have two levels of TCR gamma delta expression. Whereas TCR gamma delta(med) cells are mostly CD2(+)CD8(-) and CD2(+)CD8(+), TCR gamma delta(hi) cells are highly enriched for CD2(-)CD8(-). This distribution is independent of bacterial colonization and it is already established in the thymus prior to export of gamma delta cells to the periphery. Sorting and cultivation experiments revealed that CD2(-)CD8(-) gamma delta cells are unable to acquire CD2 and CD8, whereas CD2(+) subsets can gain or loose CD8. There is also differential susceptibility for proliferation between CD2(+) and CD2(-) gamma delta cells. Although CD2(-)CD8(-) almost do not proliferate, proliferation of CD2(+)CD8(-) and CD2(+)CD8(+) is substantial. Population of CD2(-) gamma delta cells is also absent in CD1(+) immature thymocytes. Additionally, subpopulations of CD2(+) and CD2(-) gamma delta cells in the thymus differ in expression of auxiliary surface molecules such as CD25, CD45RA/RC, and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP502%2F12%2F0110" target="_blank" >GAP502/12/0110: Úloha gamadelta T buněk při imunizaci naivního imunitního systému prasat</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Immunology

ISSN

0022-1767

e-ISSN

—

Svazek periodika

190

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

BR - Brazilská federativní republika

Počet stran výsledku

10

Strana od-do

2111-2120

Kód UT WoS článku

000315089100025

EID výsledku v databázi Scopus

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