Impact of substituent position in monosubstituted a-cyclodextrins on enantioselectivity in capillary electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10124071" target="_blank" >RIV/00216208:11310/12:10124071 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jssc.201101034" target="_blank" >http://dx.doi.org/10.1002/jssc.201101034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201101034" target="_blank" >10.1002/jssc.201101034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of substituent position in monosubstituted a-cyclodextrins on enantioselectivity in capillary electrophoresis

Popis výsledku v původním jazyce

In this study, our three recently synthesized regiospecifically monosubstituted carboxymethyl-a-cyclodextrins (CMACDs) were successfully applied for the enantiomeric separation of several biologically important low-molecular weight compounds by capillaryelectrophoresis. The enantioselectivity of the individual monosubstituted CMACDs added into the background electrolyte (BGE) was studied and compared with the mixture of three monosubstituted CMACDs and with native a-cyclodextrin at pH of the BGE ranging from 2.5 to 11. Our experiments revealed a significant influence of the position of the carboxymethyl group on the a-cyclodextrin skeleton on the enantioselectivity for all the studied analytes. Interestingly, the least common 3I-O regioisomer was revealed as the most effective chiral selector.

Název v anglickém jazyce

Impact of substituent position in monosubstituted a-cyclodextrins on enantioselectivity in capillary electrophoresis

Popis výsledku anglicky

In this study, our three recently synthesized regiospecifically monosubstituted carboxymethyl-a-cyclodextrins (CMACDs) were successfully applied for the enantiomeric separation of several biologically important low-molecular weight compounds by capillaryelectrophoresis. The enantioselectivity of the individual monosubstituted CMACDs added into the background electrolyte (BGE) was studied and compared with the mixture of three monosubstituted CMACDs and with native a-cyclodextrin at pH of the BGE ranging from 2.5 to 11. Our experiments revealed a significant influence of the position of the carboxymethyl group on the a-cyclodextrin skeleton on the enantioselectivity for all the studied analytes. Interestingly, the least common 3I-O regioisomer was revealed as the most effective chiral selector.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9306

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

811-815

Kód UT WoS článku

000303200200006

EID výsledku v databázi Scopus

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