The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F13%3A%230000110" target="_blank" >RIV/46747885:24620/13:#0000110 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/jssc.201201144/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jssc.201201144/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201201144" target="_blank" >10.1002/jssc.201201144</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis

Popis výsledku v původním jazyce

This work documents the influence of the position of single carboxymethyl group on the ?-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native ?-cyclodextrin, and commercially available carboxymethyl-?-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-mass chiral compounds were enantioseparated by CE. The results indicate that different substituent location on ?-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2I-O-regioisomer wasbetter than with native ?-cyclodextrin. Comparable results to native ?-cyclodextrin were obtained for 6I-O- regioisomer and the enantioselectivity of 3I-O-regioisomer was even worse than with native ?-cyclodextrin. Commercially available

Název v anglickém jazyce

The Study of Enantioselectivity of All Regioisomers of Mono- Carboxymethyl-a-Cyclodextrins Used as Additives in Capillary Electrophoresis

Popis výsledku anglicky

This work documents the influence of the position of single carboxymethyl group on the ?-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native ?-cyclodextrin, and commercially available carboxymethyl-?-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-mass chiral compounds were enantioseparated by CE. The results indicate that different substituent location on ?-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2I-O-regioisomer wasbetter than with native ?-cyclodextrin. Comparable results to native ?-cyclodextrin were obtained for 6I-O- regioisomer and the enantioselectivity of 3I-O-regioisomer was even worse than with native ?-cyclodextrin. Commercially available

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9306

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

36

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

1270-1274

Kód UT WoS článku

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EID výsledku v databázi Scopus

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