The influence of substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F14%3A43897172" target="_blank" >RIV/60461373:22340/14:43897172 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >http://dx.doi.org/10.1002/jssc.201400604</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >10.1002/jssc.201400604</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The influence of substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Popis výsledku v původním jazyce

Three newly synthesized chiral selectors, namely, 2I-O-, 3I-O-, and 6I-O-carboxymethyl-?-cyclodextrin, native ?-cyclodextrin, and commercially available carboxymethylated ?-cyclodextrin with degree of substitution of 3-6 were used as additives in a background electrolyte composed of phosphate buffer at 20 mmol/L concentration and pH 2.5. This systém was used for the analysis of several biologically significant low-molecular-mass chiral compounds by capillary electrophoresis. The results confirmed that the position of carboxymethyl group influences the enantioseparation efficiency of all the studied analytes. The 2I-O- and 3I-O- regioisomers provide a significantly better resolution than native ?-cyclodextrin, while the 6I-O-regioisomer gives only a slightly better enantioseparation than native ?-cyclodextrin. The application of ?-cyclodextrin possessing higher number of carboxymethyl groups led to the best resolution for the majority of the compounds analyzed.

Název v anglickém jazyce

The influence of substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Popis výsledku anglicky

Three newly synthesized chiral selectors, namely, 2I-O-, 3I-O-, and 6I-O-carboxymethyl-?-cyclodextrin, native ?-cyclodextrin, and commercially available carboxymethylated ?-cyclodextrin with degree of substitution of 3-6 were used as additives in a background electrolyte composed of phosphate buffer at 20 mmol/L concentration and pH 2.5. This systém was used for the analysis of several biologically significant low-molecular-mass chiral compounds by capillary electrophoresis. The results confirmed that the position of carboxymethyl group influences the enantioseparation efficiency of all the studied analytes. The 2I-O- and 3I-O- regioisomers provide a significantly better resolution than native ?-cyclodextrin, while the 6I-O-regioisomer gives only a slightly better enantioseparation than native ?-cyclodextrin. The application of ?-cyclodextrin possessing higher number of carboxymethyl groups led to the best resolution for the majority of the compounds analyzed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Afinitní kapilární elektromigrační metody pro selektivní nanoanalýzu biomolekul a studium jejich interakcí</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Sciences online

ISSN

1615-9314

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

2779-2784

Kód UT WoS článku

000342909300020

EID výsledku v databázi Scopus

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