The influence of the substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282374" target="_blank" >RIV/00216208:11310/14:10282374 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24620/14:#0000456

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >http://dx.doi.org/10.1002/jssc.201400604</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >10.1002/jssc.201400604</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The influence of the substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Popis výsledku v původním jazyce

Three newly synthesized chiral selectors, namely, 2(I)-O-, 3(I)-O-, and 6(I)-O-carboxymethyl--cyclodextrin, native -cyclodextrin, and commercially available carboxymethylated -cyclodextrin with degree of substitution of 3-6 were used as additives in a background electrolyte composed of phosphate buffer at 20mmol/L concentration and pH 2.5. This system was used for the analysis of several biologically significant low-molecular-mass chiral compounds by capillary electrophoresis. The results confirmed thatthe position of carboxymethyl group influences the enantioseparation efficiency of all the studied analytes. The 2(I)-O- and 3(I)-O- regioisomers provide a significantly better resolution than native -cyclodextrin, while the 6(I)-O-regioisomer gives only a slightly better enantioseparation than native -cyclodextrin. The application of -cyclodextrin possessing higher number of carboxymethyl groups led to the best resolution for the majority of the compounds analyzed.

Název v anglickém jazyce

The influence of the substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Popis výsledku anglicky

Three newly synthesized chiral selectors, namely, 2(I)-O-, 3(I)-O-, and 6(I)-O-carboxymethyl--cyclodextrin, native -cyclodextrin, and commercially available carboxymethylated -cyclodextrin with degree of substitution of 3-6 were used as additives in a background electrolyte composed of phosphate buffer at 20mmol/L concentration and pH 2.5. This system was used for the analysis of several biologically significant low-molecular-mass chiral compounds by capillary electrophoresis. The results confirmed thatthe position of carboxymethyl group influences the enantioseparation efficiency of all the studied analytes. The 2(I)-O- and 3(I)-O- regioisomers provide a significantly better resolution than native -cyclodextrin, while the 6(I)-O-regioisomer gives only a slightly better enantioseparation than native -cyclodextrin. The application of -cyclodextrin possessing higher number of carboxymethyl groups led to the best resolution for the majority of the compounds analyzed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9306

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

2779-2784

Kód UT WoS článku

000342909300020

EID výsledku v databázi Scopus

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