The study of enantioselectivity of all regioisomers of mono-carboxymethyl-b-cyclodextrin used as chiral selectors in CE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895059" target="_blank" >RIV/60461373:22340/13:43895059 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jssc.201201144" target="_blank" >http://dx.doi.org/10.1002/jssc.201201144</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201201144" target="_blank" >10.1002/jssc.201201144</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The study of enantioselectivity of all regioisomers of mono-carboxymethyl-b-cyclodextrin used as chiral selectors in CE

Popis výsledku v původním jazyce

This work documents the influence of the position of single carboxymethyl group on the beta-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native beta-cyclodextrin, and commercially available carboxymethyl-beta-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-masschiral compounds were enantioseparated by CE. The results indicate that different substituent location on beta-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2(I)-O-regioisomer was better than with native beta-cyclodextrin. Comparable results to native beta-cyclodextrin were obtained for 6(I)-O-regioisomer and the enantioselectivity of 3(I)-O-regioisomer was even worse than with native beta-cyclodextri

Název v anglickém jazyce

The study of enantioselectivity of all regioisomers of mono-carboxymethyl-b-cyclodextrin used as chiral selectors in CE

Popis výsledku anglicky

This work documents the influence of the position of single carboxymethyl group on the beta-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native beta-cyclodextrin, and commercially available carboxymethyl-beta-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-masschiral compounds were enantioseparated by CE. The results indicate that different substituent location on beta-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2(I)-O-regioisomer was better than with native beta-cyclodextrin. Comparable results to native beta-cyclodextrin were obtained for 6(I)-O-regioisomer and the enantioselectivity of 3(I)-O-regioisomer was even worse than with native beta-cyclodextri

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Afinitní kapilární elektromigrační metody pro selektivní nanoanalýzu biomolekul a studium jejich interakcí</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9306

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

1270-1274

Kód UT WoS článku

000319865700015

EID výsledku v databázi Scopus

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