Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10126423" target="_blank" >RIV/00216208:11310/12:10126423 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review)

Popis výsledku v původním jazyce

Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between studied analytes and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review should provide evidence that the electrochemical approach brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between organic xenobiotic compounds and DNA.

Název v anglickém jazyce

Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review)

Popis výsledku anglicky

Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between studied analytes and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review should provide evidence that the electrochemical approach brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between organic xenobiotic compounds and DNA.

Druh

O - Ostatní výsledky

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů