Novel Electrochemical DNA Biosensors as Tools for Investigation and Detection of DNA Damage
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10419822" target="_blank" >RIV/00216208:11310/16:10419822 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1007/11663_2015_5002" target="_blank" >https://doi.org/10.1007/11663_2015_5002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/11663_2015_5002" target="_blank" >10.1007/11663_2015_5002</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Novel Electrochemical DNA Biosensors as Tools for Investigation and Detection of DNA Damage
Popis výsledku v původním jazyce
Supramolecular interactions of various organic xenobiotic compounds with deoxyribonucleic acid (DNA) are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between a studied analyte and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review summarizes our results obtained during the last 5 years in the field of novel electrochemical DNA biosensors utilizing carbon-based transducers as substrates for immobilization of DNA. It should provide evidence that the electrochemical approach (employing simple, fast, sensitive, and inexpensive DNA biosensors as tools for investigation and detection of DNA damage) brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between xenobiotic compounds and DNA.
Název v anglickém jazyce
Novel Electrochemical DNA Biosensors as Tools for Investigation and Detection of DNA Damage
Popis výsledku anglicky
Supramolecular interactions of various organic xenobiotic compounds with deoxyribonucleic acid (DNA) are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between a studied analyte and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review summarizes our results obtained during the last 5 years in the field of novel electrochemical DNA biosensors utilizing carbon-based transducers as substrates for immobilization of DNA. It should provide evidence that the electrochemical approach (employing simple, fast, sensitive, and inexpensive DNA biosensors as tools for investigation and detection of DNA damage) brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between xenobiotic compounds and DNA.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/GP13-23337P" target="_blank" >GP13-23337P: Komplexní diagnostický přístup při hodnocení interakce DNA s organickými xenobiotiky pomocí elektrochemických nanostrukturovaných DNA biosenzorů</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Trends in Bioelectroanalysis. Bioanalytical Reviews
ISBN
978-3-319-48483-9
Počet stran výsledku
19
Strana od-do
203-221
Počet stran knihy
344
Název nakladatele
Springer, Cham
Místo vydání
Cham
Kód UT WoS kapitoly
—