Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10127237" target="_blank" >RIV/00216208:11310/12:10127237 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c2dt30858d" target="_blank" >http://dx.doi.org/10.1039/c2dt30858d</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c2dt30858d" target="_blank" >10.1039/c2dt30858d</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields

Popis výsledku v původním jazyce

Middle-molecular-weight MRI contrast agents based on conjugates of a phosphinic acid DOTA analogue, 1,4,7,10-tetraazacyclododecane-4,7,10-triacetic-1-{methyl[(4-aminophenyl ) methyl] phosphinic acid} (DO3AP(ABn)), with amino-substituted cyclodextrins were prepared and studied by a variety of physicochemical methods. The conjugates were formed by reaction of the corresponding isothiocyanate with per-6-amino-alpha/beta-cyclodextrin and were complexed with the Ln(III) ion to get the final complexes, (LnL)(6)-alpha-CD and (LnL)(7)-beta-CD. Solution structure of the complexes was estimated by investigation of the Eu-III complexes. The Gd-III conjugate complexes are endowed with a short water residence time (tau(M) similar to 10-15 ns at 298 K) and a high abundance of the twisted-square antiprismatic diastereoisomer. They show a high H-1 relaxivity at high fields due to a convenient combination of the fast water exchange rate and the slow rate of the molecular tumbling given by their macromo

Název v anglickém jazyce

Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields

Popis výsledku anglicky

Middle-molecular-weight MRI contrast agents based on conjugates of a phosphinic acid DOTA analogue, 1,4,7,10-tetraazacyclododecane-4,7,10-triacetic-1-{methyl[(4-aminophenyl ) methyl] phosphinic acid} (DO3AP(ABn)), with amino-substituted cyclodextrins were prepared and studied by a variety of physicochemical methods. The conjugates were formed by reaction of the corresponding isothiocyanate with per-6-amino-alpha/beta-cyclodextrin and were complexed with the Ln(III) ion to get the final complexes, (LnL)(6)-alpha-CD and (LnL)(7)-beta-CD. Solution structure of the complexes was estimated by investigation of the Eu-III complexes. The Gd-III conjugate complexes are endowed with a short water residence time (tau(M) similar to 10-15 ns at 298 K) and a high abundance of the twisted-square antiprismatic diastereoisomer. They show a high H-1 relaxivity at high fields due to a convenient combination of the fast water exchange rate and the slow rate of the molecular tumbling given by their macromo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Nové třídy kontrastních látek pro tomografii magnetické rezonance</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dalton Transactions

ISSN

1477-9226

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

43

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

13509-13519

Kód UT WoS článku

000309885500037

EID výsledku v databázi Scopus

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