Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10127593" target="_blank" >RIV/00216208:11310/12:10127593 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388980:_____/12:00383643 RIV/61388963:_____/12:00383643

Výsledek na webu

<a href="http://dx.doi.org/10.1351/PAC-CON-12-04-03" target="_blank" >http://dx.doi.org/10.1351/PAC-CON-12-04-03</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1351/PAC-CON-12-04-03" target="_blank" >10.1351/PAC-CON-12-04-03</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances

Popis výsledku v původním jazyce

A synthesis of the first double-decker sandwich ion [(1',2'-C 2B 9H 11)-3,3'-Co-(1,2-C 2B 8H 10)-6,3"-Co-(1",2"-C 2B 9H 11)] 2- (DD 2-) derivatives is described, having been developed in connection with our search for biologically active substances. A series of B-substituted hydroxyl derivatives was prepared by direct hydroxylation of the ion using aqueous sulfuric acid. Two isomers of monohydroxy derivatives were isolated. The main product was substituted at the central "canastide" ion fragment, whereas the substitution site for the minor isomer corresponded to a B(8) atom of one of the terminal 11-vertex dicarbollide parts. Similarly, the disubstitution occurred slightly more preferentially on the "canastide" fragment providing the main isomeric derivative with a symmetric structure. The cesium salt of this ion was characterized by X-ray diffraction. Two other isomeric species have one substituent sitting on the "canastide" ion and the second present on the dicarbollide ligand in apa

Název v anglickém jazyce

Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances

Popis výsledku anglicky

A synthesis of the first double-decker sandwich ion [(1',2'-C 2B 9H 11)-3,3'-Co-(1,2-C 2B 8H 10)-6,3"-Co-(1",2"-C 2B 9H 11)] 2- (DD 2-) derivatives is described, having been developed in connection with our search for biologically active substances. A series of B-substituted hydroxyl derivatives was prepared by direct hydroxylation of the ion using aqueous sulfuric acid. Two isomers of monohydroxy derivatives were isolated. The main product was substituted at the central "canastide" ion fragment, whereas the substitution site for the minor isomer corresponded to a B(8) atom of one of the terminal 11-vertex dicarbollide parts. Similarly, the disubstitution occurred slightly more preferentially on the "canastide" fragment providing the main isomeric derivative with a symmetric structure. The cesium salt of this ion was characterized by X-ray diffraction. Two other isomeric species have one substituent sitting on the "canastide" ion and the second present on the dicarbollide ligand in apa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/IAAX00320901" target="_blank" >IAAX00320901: Funkční deriváty klastrových sloučenin boru jako inhibitory virových enzymů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pure and Applied Chemistry

ISSN

0033-4545

e-ISSN

—

Svazek periodika

84

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

2243-2262

Kód UT WoS článku

000311631700006

EID výsledku v databázi Scopus

—