Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10133860" target="_blank" >RIV/00216208:11310/13:10133860 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.jorganchem.2012.10.009" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2012.10.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2012.10.009" target="_blank" >10.1016/j.jorganchem.2012.10.009</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity
Popis výsledku v původním jazyce
A series of heterodinuclear p-cymene ruthenium ferrocene complexes, [(eta(6)-p-MeC6H4Pri)RuCl2(Ph2PfcCONHRCO2Me-kappa P)] (R = (S)-Me: 6, R = (S)-CHMe2: 7, R = (S)-CH2OMe: 8, R = (S)-CH2SMe: 9, R = (S)-CH2CH2CO2Me: 10) have been synthesized from p-cymeneruthenium dichloride dimer and phosphinoferrocene ligands bearing carboxamide substituents derived from amino acids, Ph(2)PfcCONHRCO(2)Me (R = (S)-Me: 1, R = (S)-CHMe2: 2, R = (S)-CH2OMe: 3, R = (S)-CH2SMe: 4, R = (S)-CH2CH2CO2Me: 5, fc = ferrocene-1,1'-diyl). All new compounds, 3-10, were fully characterized by elemental analysis, multinuclear NMR and IR spectroscopy and electrospray ionisation mass spectrometry, and their electrochemical properties were studied by cyclic voltammetry at a platinum disc electrode. The cytotoxicity of 6-10 was studied on human ovarian cancer cells. The related glycine derivatives [(eta(6)-arene) RuCl2(Ph2PfcCONHCH2CO2Me-kappa P)] (arene = C6H6: 11a, arene = p-MeC6H4Pri: 11b, arene = C6Me6: 11c), [(eta(6
Název v anglickém jazyce
Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity
Popis výsledku anglicky
A series of heterodinuclear p-cymene ruthenium ferrocene complexes, [(eta(6)-p-MeC6H4Pri)RuCl2(Ph2PfcCONHRCO2Me-kappa P)] (R = (S)-Me: 6, R = (S)-CHMe2: 7, R = (S)-CH2OMe: 8, R = (S)-CH2SMe: 9, R = (S)-CH2CH2CO2Me: 10) have been synthesized from p-cymeneruthenium dichloride dimer and phosphinoferrocene ligands bearing carboxamide substituents derived from amino acids, Ph(2)PfcCONHRCO(2)Me (R = (S)-Me: 1, R = (S)-CHMe2: 2, R = (S)-CH2OMe: 3, R = (S)-CH2SMe: 4, R = (S)-CH2CH2CO2Me: 5, fc = ferrocene-1,1'-diyl). All new compounds, 3-10, were fully characterized by elemental analysis, multinuclear NMR and IR spectroscopy and electrospray ionisation mass spectrometry, and their electrochemical properties were studied by cyclic voltammetry at a platinum disc electrode. The cytotoxicity of 6-10 was studied on human ovarian cancer cells. The related glycine derivatives [(eta(6)-arene) RuCl2(Ph2PfcCONHCH2CO2Me-kappa P)] (arene = C6H6: 11a, arene = p-MeC6H4Pri: 11b, arene = C6Me6: 11c), [(eta(6
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CA - Anorganická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Organometallic Chemistry
ISSN
0022-328X
e-ISSN
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Svazek periodika
723
Číslo periodika v rámci svazku
January
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
6
Strana od-do
233-238
Kód UT WoS článku
000311680100033
EID výsledku v databázi Scopus
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