How is Ga-68 Labeling of Macrocyclic Chelators Influenced by Metal Ion Contaminants in Ge-68/Ga-68 Generator Eluates?

Kód výsledku v IS VaVaI

RIV/00216208:11310/13:10139605 - isvavai.cz

Výsledek na webu

http://dx.doi.org/10.1002/cmdc.201200471

DOI - Digital Object Identifier

10.1002/cmdc.201200471

Jazyk výsledku

angličtina

Název v původním jazyce

How is Ga-68 Labeling of Macrocyclic Chelators Influenced by Metal Ion Contaminants in Ge-68/Ga-68 Generator Eluates?

Popis výsledku v původním jazyce

To assess the influence of Zn2+, Cu2+, Fe3+, Al3+, Ti-IV, and Sn-IV on incorporation of Ga-68(3+) into pendant-arm macrocyclic chelators, the Ga-68 labeling of 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA), 1,4,7-triazacyclononane-1,4,7-tris[methyl(2-carboxyethyl) phosphinic acid]) (TRAP), and 1,4,7-triazacyclononane-1-[methyl(2-carboxyethyl) phosphinic acid]-4,7-bis-[methyl(2-hydroxymethyl)phosphinic acid] (NOPO), as well as theirpeptide conjugates, was investigated in the presence of varying concentrations of these metal ions. The Ga-68 labeling yield for carboxylate-type chelators NOTA and DOTA is decreased at lower metal ion contaminant concentrations compared with phosphinate-type chelators TRAP and NOPO. The latter are able to rapidly exchange coordinated ZnII with Ga-68(3+), as confirmed by mass spectrometry and P-31 NMR spectroscopy. Ga-68 labeling of ZnII complexes of TRAP and NOPO proceeds as efficient a

Název v anglickém jazyce

How is Ga-68 Labeling of Macrocyclic Chelators Influenced by Metal Ion Contaminants in Ge-68/Ga-68 Generator Eluates?

Popis výsledku anglicky

To assess the influence of Zn2+, Cu2+, Fe3+, Al3+, Ti-IV, and Sn-IV on incorporation of Ga-68(3+) into pendant-arm macrocyclic chelators, the Ga-68 labeling of 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA), 1,4,7-triazacyclononane-1,4,7-tris[methyl(2-carboxyethyl) phosphinic acid]) (TRAP), and 1,4,7-triazacyclononane-1-[methyl(2-carboxyethyl) phosphinic acid]-4,7-bis-[methyl(2-hydroxymethyl)phosphinic acid] (NOPO), as well as theirpeptide conjugates, was investigated in the presence of varying concentrations of these metal ions. The Ga-68 labeling yield for carboxylate-type chelators NOTA and DOTA is decreased at lower metal ion contaminant concentrations compared with phosphinate-type chelators TRAP and NOPO. The latter are able to rapidly exchange coordinated ZnII with Ga-68(3+), as confirmed by mass spectrometry and P-31 NMR spectroscopy. Ga-68 labeling of ZnII complexes of TRAP and NOPO proceeds as efficient a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemMedChem

ISSN

1860-7179

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

95-103

Kód UT WoS článku

000314172100012

EID výsledku v databázi Scopus

—