A NO photoreleasing supramolecular hydrogel with bactericidal action

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10139607" target="_blank" >RIV/00216208:11310/13:10139607 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c3tb20473a" target="_blank" >http://dx.doi.org/10.1039/c3tb20473a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c3tb20473a" target="_blank" >10.1039/c3tb20473a</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A NO photoreleasing supramolecular hydrogel with bactericidal action

Popis výsledku v původním jazyce

We have developed an engineered hydrogel formed, in the absence of any toxic solvents or reagents, by spontaneous self-assembly of three key components: a poly-beta-cyclodextrin polymer (1), a hydrophobically modified dextran (2) and a nitric oxide (NO)photodonor bearing an adamantyl appendage (3). The formation of this supramolecular assembly is based on a "lock-and-key" mechanism in which the alkyl side chains of 2 and the adamantane moiety of 3 form inclusion complexes with the beta-CD cavities of 1. The multivalent character of the interactions between all components and the insolubility of the NO photodonor in an aqueous medium ensure the stability of the hydrogel and the total lack of leaching of the photoactive component from the gel network under physiological conditions, even in the absence of protective coating agents. The photochemical properties of the NO photodonor are well preserved in the supramolecular matrix as demonstrated by the remote-controlled release of NO throu

Název v anglickém jazyce

A NO photoreleasing supramolecular hydrogel with bactericidal action

Popis výsledku anglicky

We have developed an engineered hydrogel formed, in the absence of any toxic solvents or reagents, by spontaneous self-assembly of three key components: a poly-beta-cyclodextrin polymer (1), a hydrophobically modified dextran (2) and a nitric oxide (NO)photodonor bearing an adamantyl appendage (3). The formation of this supramolecular assembly is based on a "lock-and-key" mechanism in which the alkyl side chains of 2 and the adamantane moiety of 3 form inclusion complexes with the beta-CD cavities of 1. The multivalent character of the interactions between all components and the insolubility of the NO photodonor in an aqueous medium ensure the stability of the hydrogel and the total lack of leaching of the photoactive component from the gel network under physiological conditions, even in the absence of protective coating agents. The photochemical properties of the NO photodonor are well preserved in the supramolecular matrix as demonstrated by the remote-controlled release of NO throu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

28

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

3458-3463

Kód UT WoS článku

000320951700004

EID výsledku v databázi Scopus

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