A New Hyaluronan Modified with beta-Cyclodextrin on Hydroxymethyl Groups Forms a Dynamic Supramolecular Network

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73598520" target="_blank" >RIV/61989592:15310/19:73598520 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/1420-3049/24/21/3849/htm" target="_blank" >https://www.mdpi.com/1420-3049/24/21/3849/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24213849" target="_blank" >10.3390/molecules24213849</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A New Hyaluronan Modified with beta-Cyclodextrin on Hydroxymethyl Groups Forms a Dynamic Supramolecular Network

Popis výsledku v původním jazyce

A new hyaluronan derivative modified with beta-cyclodextrin units (CD-HA) was prepared via the click reaction between propargylated hyaluronan and monoazido-cyclodextrin (CD) to achieve a degree of substitution of 4%. The modified hyaluronan was characterized by H-1-nuclear magnetic resonance spectroscopy (NMR) and size exclusion chromatography. Subsequent H-1-NMR and isothermal calorimetric titration experiments revealed that the CD units on CD-HA can form virtual 1:1, 1:2, and 1:3 complexes with one-, two-, and three-site adamantane-based guests, respectively. These results imply that the CD-HA chains used the multitopic guests to form a supramolecular cross-linked network. The free CD-HA polymer was readily restored by the addition of a competing macrocycle, which entrapped the cross-linking guests. Thus, we demonstrated that the new CD-HA polymer is a promising component for the construction of chemical stimuli-responsive supramolecular architectures.

Název v anglickém jazyce

A New Hyaluronan Modified with beta-Cyclodextrin on Hydroxymethyl Groups Forms a Dynamic Supramolecular Network

Popis výsledku anglicky

A new hyaluronan derivative modified with beta-cyclodextrin units (CD-HA) was prepared via the click reaction between propargylated hyaluronan and monoazido-cyclodextrin (CD) to achieve a degree of substitution of 4%. The modified hyaluronan was characterized by H-1-nuclear magnetic resonance spectroscopy (NMR) and size exclusion chromatography. Subsequent H-1-NMR and isothermal calorimetric titration experiments revealed that the CD units on CD-HA can form virtual 1:1, 1:2, and 1:3 complexes with one-, two-, and three-site adamantane-based guests, respectively. These results imply that the CD-HA chains used the multitopic guests to form a supramolecular cross-linked network. The free CD-HA polymer was readily restored by the addition of a competing macrocycle, which entrapped the cross-linking guests. Thus, we demonstrated that the new CD-HA polymer is a promising component for the construction of chemical stimuli-responsive supramolecular architectures.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MOLECULES

ISSN

1420-3049

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

"3849-1"-"3849-11"

Kód UT WoS článku

000498055500038

EID výsledku v databázi Scopus

2-s2.0-85074204201