Adamantylated cross-linkers and -cyclodextrin-modified hyaluronan form supramolecular 3D networks with adjustable mechanical properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571098" target="_blank" >RIV/70883521:28110/23:63571098 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28140/23:63571098 RIV/70883521:28610/23:63571098

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Adamantylated cross-linkers and -cyclodextrin-modified hyaluronan form supramolecular 3D networks with adjustable mechanical properties

Popis výsledku v původním jazyce

Biocompatible and self-healing hydrogels are highly advantageous materials for use inside living organisms and the environment. Most notably, those physically cross-linked three-dimensional (3D) networks employing two distinct polymers bearing supramolecular units in the multipoint molecular recognition process are extensively studied1. Our work attempts to verify an approach based on cross-linking supramolecular host entity-modified polymer chains with low-molecular-weight counterparts. Adamantane (Ad)-based star-like molecules were employed in this manner together with -cyclodextrin ( -CD) units attached covalently to hyaluronan (HA) polymer2. Formation of host-guest complexes was confirmed by NMR and calorimetry titrations. The resulting supramolecular network was subjected to rheological measurements. From the data obtained it can be concluded that the chemical nature of the cross-linking agent (amides vs esters) influences the network properties more than length of cross-linker&apos;s arm. Concerning hyaluronan, the length of the polymer chain affects network&apos;s mechanical properties to a greater extent than degree of substitution with -CD carriers. In summary, the concept of multitopic low-molecular-weight guests acting as modular cross-linkers for tuning the physical properties of the supramolecular network was demonstrated.

Název v anglickém jazyce

Adamantylated cross-linkers and -cyclodextrin-modified hyaluronan form supramolecular 3D networks with adjustable mechanical properties

Popis výsledku anglicky

Biocompatible and self-healing hydrogels are highly advantageous materials for use inside living organisms and the environment. Most notably, those physically cross-linked three-dimensional (3D) networks employing two distinct polymers bearing supramolecular units in the multipoint molecular recognition process are extensively studied1. Our work attempts to verify an approach based on cross-linking supramolecular host entity-modified polymer chains with low-molecular-weight counterparts. Adamantane (Ad)-based star-like molecules were employed in this manner together with -cyclodextrin ( -CD) units attached covalently to hyaluronan (HA) polymer2. Formation of host-guest complexes was confirmed by NMR and calorimetry titrations. The resulting supramolecular network was subjected to rheological measurements. From the data obtained it can be concluded that the chemical nature of the cross-linking agent (amides vs esters) influences the network properties more than length of cross-linker&apos;s arm. Concerning hyaluronan, the length of the polymer chain affects network&apos;s mechanical properties to a greater extent than degree of substitution with -CD carriers. In summary, the concept of multitopic low-molecular-weight guests acting as modular cross-linkers for tuning the physical properties of the supramolecular network was demonstrated.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů