Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10159019" target="_blank" >RIV/00216208:11310/13:10159019 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/13:00396273 RIV/00216224:14310/13:00073056

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1471-2148-13-194" target="_blank" >http://dx.doi.org/10.1186/1471-2148-13-194</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2148-13-194" target="_blank" >10.1186/1471-2148-13-194</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

Popis výsledku v původním jazyce

In this study we analysed the natural variation and the evolutionary processes acting on two genes involved in the innate-immunity recognition of Microbe-Associated Molecular Patterns (MAMPs). We sequenced genes encoding Toll-like receptor 4 (Tlr4) and 7(Tlr7), two of the key bacterial- and viralsensing receptors of innate immunity, across 23 species within the subfamily Murinae. Although we have shown that the phylogeny of both Tlr genes is largely congruent with the phylogeny of rodents based on a comparably sized non-immune sequence dataset, we also identified several potentially important discrepancies. The sequence analyses revealed that major parts of both Tlrs are evolving under strong purifying selection, likely due to functional constraints.Yet, also several signatures of positive selection have been found in both genes, with more intense signal in the bacterial-sensing Tlr4 than in the viral-sensing Tlr7. 92% and 100% of sites evolving under positive selection in Tlr4 and T

Název v anglickém jazyce

Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

Popis výsledku anglicky

In this study we analysed the natural variation and the evolutionary processes acting on two genes involved in the innate-immunity recognition of Microbe-Associated Molecular Patterns (MAMPs). We sequenced genes encoding Toll-like receptor 4 (Tlr4) and 7(Tlr7), two of the key bacterial- and viralsensing receptors of innate immunity, across 23 species within the subfamily Murinae. Although we have shown that the phylogeny of both Tlr genes is largely congruent with the phylogeny of rodents based on a comparably sized non-immune sequence dataset, we also identified several potentially important discrepancies. The sequence analyses revealed that major parts of both Tlrs are evolving under strong purifying selection, likely due to functional constraints.Yet, also several signatures of positive selection have been found in both genes, with more intense signal in the bacterial-sensing Tlr4 than in the viral-sensing Tlr7. 92% and 100% of sites evolving under positive selection in Tlr4 and T

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA206%2F08%2F0640" target="_blank" >GA206/08/0640: Immunogenetické studium hybridní zóny myší domácích</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Evolutionary Biology

ISSN

1471-2148

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

194

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

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Kód UT WoS článku

000324749400001

EID výsledku v databázi Scopus

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