Perspectives and industrial potential of PGA selectivity and promiscuity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191753" target="_blank" >RIV/00216208:11310/13:10191753 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biotechadv.2013.07.005" target="_blank" >http://dx.doi.org/10.1016/j.biotechadv.2013.07.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2013.07.005" target="_blank" >10.1016/j.biotechadv.2013.07.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Perspectives and industrial potential of PGA selectivity and promiscuity

Popis výsledku v původním jazyce

Penicillin G acylases (PGAs) are robust industrial catalysts used for biotransformation of ?-lactams into key intermediates for chemical production of semi-synthetic ?-lactam antibiotics by hydrolysis of natural penicillins. They are used also in reverse, kinetically controlled synthetic reactions for large-scale productions of these antibiotics from corresponding beta-lactam nuclei and activated acyl donors. Further biocatalytic applications of PGAs have recently been described: catalysis of peptide syntheses and the resolutions of racemic mixtures for the production of enantiopure active pharmaceutical ingredients that are based on enantioselective acylation or chiral hydrolysis. Moreover, PGAs rank among promiscuous enzymes because they also catalyze reactions such as trans-esterification, Markovnikov addition or Henry reaction. This particular biocatalytic versatility represents a driving force for the discovery of novel members of this enzyme family and further research into the c

Název v anglickém jazyce

Perspectives and industrial potential of PGA selectivity and promiscuity

Popis výsledku anglicky

Penicillin G acylases (PGAs) are robust industrial catalysts used for biotransformation of ?-lactams into key intermediates for chemical production of semi-synthetic ?-lactam antibiotics by hydrolysis of natural penicillins. They are used also in reverse, kinetically controlled synthetic reactions for large-scale productions of these antibiotics from corresponding beta-lactam nuclei and activated acyl donors. Further biocatalytic applications of PGAs have recently been described: catalysis of peptide syntheses and the resolutions of racemic mixtures for the production of enantiopure active pharmaceutical ingredients that are based on enantioselective acylation or chiral hydrolysis. Moreover, PGAs rank among promiscuous enzymes because they also catalyze reactions such as trans-esterification, Markovnikov addition or Henry reaction. This particular biocatalytic versatility represents a driving force for the discovery of novel members of this enzyme family and further research into the c

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biotechnology Advances

ISSN

0734-9750

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

15

Strana od-do

1458-1472

Kód UT WoS článku

000329081200026

EID výsledku v databázi Scopus

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