Current state and perspectives of penicillin G acylase-based biocatalyses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10289021" target="_blank" >RIV/00216208:11310/14:10289021 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/14:00435793

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00253-013-5492-7" target="_blank" >http://dx.doi.org/10.1007/s00253-013-5492-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00253-013-5492-7" target="_blank" >10.1007/s00253-013-5492-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current state and perspectives of penicillin G acylase-based biocatalyses

Popis výsledku v původním jazyce

In the course of more than 60-year history, penicillin G acylase (PGA) gained a unique position among enzymes used by pharmaceutical industry for production of beta-lactam antibiotics. Kinetically controlled enzymatic syntheses of cephalosporins of novelgenerations in which PGA catalyzes coupling of activated acyl donor with nucleophile belong among the latest large-scale applications. Contrary to rather specific roles of other enzymes involved in beta-lactam biocatalyses, the PGA seems to have the greatest potential. On the laboratory scale, other applications with industrial potential were described, e.g., directed evolution of the enzyme to meet specific demands of industrial processes or its modification into the enzyme catalyzing reactions with novel substrates. The fact that beta-lactams represent the most important group of antibiotics comprising 65 % of the world antibiotic market explains such a tremendous and continuous interest in this enzyme. Indeed, the annual consumption

Název v anglickém jazyce

Current state and perspectives of penicillin G acylase-based biocatalyses

Popis výsledku anglicky

In the course of more than 60-year history, penicillin G acylase (PGA) gained a unique position among enzymes used by pharmaceutical industry for production of beta-lactam antibiotics. Kinetically controlled enzymatic syntheses of cephalosporins of novelgenerations in which PGA catalyzes coupling of activated acyl donor with nucleophile belong among the latest large-scale applications. Contrary to rather specific roles of other enzymes involved in beta-lactam biocatalyses, the PGA seems to have the greatest potential. On the laboratory scale, other applications with industrial potential were described, e.g., directed evolution of the enzyme to meet specific demands of industrial processes or its modification into the enzyme catalyzing reactions with novel substrates. The fact that beta-lactams represent the most important group of antibiotics comprising 65 % of the world antibiotic market explains such a tremendous and continuous interest in this enzyme. Indeed, the annual consumption

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Microbiology and Biotechnology

ISSN

0175-7598

e-ISSN

—

Svazek periodika

98

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

2867-2879

Kód UT WoS článku

000334167900003

EID výsledku v databázi Scopus

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