Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10218674" target="_blank" >RIV/00216208:11310/14:10218674 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0021967314009649/1-s2.0-S0021967314009649-main.pdf?_tid=a08e9c2c-a563-11e4-9b5e-00000aab0f02&acdnat=1422280984_678c9a6ddb67419a5eabff83ae8279b0" target="_blank" >http://ac.els-cdn.com/S0021967314009649/1-s2.0-S0021967314009649-main.pdf?_tid=a08e9c2c-a563-11e4-9b5e-00000aab0f02&acdnat=1422280984_678c9a6ddb67419a5eabff83ae8279b0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chroma.2014.06.040" target="_blank" >10.1016/j.chroma.2014.06.040</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode

Popis výsledku v původním jazyce

Derivatized polysaccharide-based columns have high enantiodiscrimination potential mainly in normal phase separation mode. In this work chiral recognition ability of four immobilized polysaccharide-derived chiral stationary phases was evaluated under reversed phase conditions. A set of 30 chiral compounds, particularly drugs possessing various functional groups was used for testing. Baseline enantioseparation was achieved for 17 of them. In general, amylose-based chiral stationary phases showed higher enantio- selectivity than the cellulose-based ones, mainly for acidic and bifunctional compounds. The influence of the type and pH of the aqueous mobile phase constituents a well as the role of the organic modifier on the enantioselective separation ability of the stationary phases were also investigated and compared. Com- plementary separations were obtained on the amylose- and cellulose-based columns. The immobilized polysaccharide-based chiral stationary phases were shown to be useful

Název v anglickém jazyce

Enantioselective potential of chiral stationary phases based on immobilized polysaccharides in reversed phase mode

Popis výsledku anglicky

Derivatized polysaccharide-based columns have high enantiodiscrimination potential mainly in normal phase separation mode. In this work chiral recognition ability of four immobilized polysaccharide-derived chiral stationary phases was evaluated under reversed phase conditions. A set of 30 chiral compounds, particularly drugs possessing various functional groups was used for testing. Baseline enantioseparation was achieved for 17 of them. In general, amylose-based chiral stationary phases showed higher enantio- selectivity than the cellulose-based ones, mainly for acidic and bifunctional compounds. The influence of the type and pH of the aqueous mobile phase constituents a well as the role of the organic modifier on the enantioselective separation ability of the stationary phases were also investigated and compared. Com- plementary separations were obtained on the amylose- and cellulose-based columns. The immobilized polysaccharide-based chiral stationary phases were shown to be useful

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chromatography A

ISSN

0021-9673

e-ISSN

—

Svazek periodika

1363

Číslo periodika v rámci svazku

OCT 10

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

155-161

Kód UT WoS článku

000343359100019

EID výsledku v databázi Scopus

—