Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10293125" target="_blank" >RIV/00216208:11310/15:10293125 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs10337-014-2804-8" target="_blank" >http://link.springer.com/article/10.1007%2Fs10337-014-2804-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-014-2804-8" target="_blank" >10.1007/s10337-014-2804-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

Popis výsledku v původním jazyce

A set of 31 structurally different chiral pharmaceutical compounds was used as model analytes for investigation of the enantioselective potential of two immobilized polysaccharide-based chiral stationary phases under normal and reversed phase separationconditions. These chiral stationary phases differed in the polymeric backbone, amylose or cellulose, but possessed the same derivatization functionality. The results showed that the tris(3,5-dimethylphenylcarbamate) of amylose and cellulose have very broad, and often complementary, enantiorecognition abilities. In general, normal phase separation mode seemed to be more advantageous for separation of the majority of studied pharmaceuticals no matter if amylose- or cellulose-based columns were used. However, in certain cases the reversed phase separation system yielded better results. The combination of these two immobilized chiral stationary phases offers a powerful tool for enantioseparation of different types of pharmaceuticals in the

Název v anglickém jazyce

Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC

Popis výsledku anglicky

A set of 31 structurally different chiral pharmaceutical compounds was used as model analytes for investigation of the enantioselective potential of two immobilized polysaccharide-based chiral stationary phases under normal and reversed phase separationconditions. These chiral stationary phases differed in the polymeric backbone, amylose or cellulose, but possessed the same derivatization functionality. The results showed that the tris(3,5-dimethylphenylcarbamate) of amylose and cellulose have very broad, and often complementary, enantiorecognition abilities. In general, normal phase separation mode seemed to be more advantageous for separation of the majority of studied pharmaceuticals no matter if amylose- or cellulose-based columns were used. However, in certain cases the reversed phase separation system yielded better results. The combination of these two immobilized chiral stationary phases offers a powerful tool for enantioseparation of different types of pharmaceuticals in the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

<a href="/cs/project/LH11018" target="_blank" >LH11018: Cyklofruktany a jejich deriváty jako nové chirální selektory pro kapalinovou chromatografii a kapilární elektroforézu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chromatographia

ISSN

0009-5893

e-ISSN

—

Svazek periodika

79

Číslo periodika v rámci svazku

13-14

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

909-915

Kód UT WoS článku

000357460300008

EID výsledku v databázi Scopus

2-s2.0-84943350557