Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10271592" target="_blank" >RIV/00216208:11310/14:10271592 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/14:00431273 RIV/61388963:_____/14:00431273

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003" target="_blank" >http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003" target="_blank" >10.1016/j.freeradbiomed.2013.10.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

Popis výsledku v původním jazyce

Tumor-initiating cells (TICs) often survive therapy and give rise to second-line tumors. We tested the plausibility of sphere cultures as models of TICs. Microarray data and microRNA data analysis confirmed the validity of spheres as models of TICs for breast and prostate cancer as well as mesothelioma cell lines. Microarray data analysis revealed the Trp pathway as the only pathway upregulated significantly in all types of studied TICs, with increased levels of indoleamine-2,3-dioxygenase-1 (IDO1), therate-limiting enzyme of Trp metabolism along the kynurenine pathway. All types of TICs also expressed higher levels of the Trp uptake system consisting of CD98 and LAT1 with functional consequences. IDO1 expression was regulated via both transcriptionaland posttranscriptional mechanisms, depending on the cancer type. Serial transplantation of TICs in mice resulted in gradually increased IDO1. Mitocans, represented by et-tocopheryl succinate and mitochondrially targeted vitamin E succin

Název v anglickém jazyce

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

Popis výsledku anglicky

Tumor-initiating cells (TICs) often survive therapy and give rise to second-line tumors. We tested the plausibility of sphere cultures as models of TICs. Microarray data and microRNA data analysis confirmed the validity of spheres as models of TICs for breast and prostate cancer as well as mesothelioma cell lines. Microarray data analysis revealed the Trp pathway as the only pathway upregulated significantly in all types of studied TICs, with increased levels of indoleamine-2,3-dioxygenase-1 (IDO1), therate-limiting enzyme of Trp metabolism along the kynurenine pathway. All types of TICs also expressed higher levels of the Trp uptake system consisting of CD98 and LAT1 with functional consequences. IDO1 expression was regulated via both transcriptionaland posttranscriptional mechanisms, depending on the cancer type. Serial transplantation of TICs in mice resulted in gradually increased IDO1. Mitocans, represented by et-tocopheryl succinate and mitochondrially targeted vitamin E succin

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Free Radical Biology and Medicine

ISSN

0891-5849

e-ISSN

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Svazek periodika

67

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

41-50

Kód UT WoS článku

000331854200005

EID výsledku v databázi Scopus

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