Drugs that kill cancer stem-like cells

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Drugs that kill cancer stem-like cells

Popis výsledku v původním jazyce

A review desribes mechanisms by which a host of agents kill (or fail to kill) CSCs. The authors characterize three types of CSCs, namely, breast and prostate cancer and mesothelioma cultured as cancer cell spheres in vitro. The analysis of their stemnessis then taken to a new plane by using microarray analysis and the tools of bioinformatics. The tryptophan pathway was the most activated of all pathways whose activation was common to the cancer cells studied suggesting that inhibitors of indoleamine-2,3-dioxygenase (IDO), an enzyme in the tryptophan to N-formyl kynurenin pathway, would be useful for killing CSCs. The authors then develop the principle of mitochondrial targeting by synthesizing a mitochondrially targeted vitamin E succinate [MitoVES] that crosses the mitochondrial inner membrane and acts by targeting the mitochondrial complex II. MitoVES is probably thus far the best characterized agent toxic to CSCs. Two-pronged approach to therapy, therefore, might be desirable.

Název v anglickém jazyce

Drugs that kill cancer stem-like cells

Popis výsledku anglicky

A review desribes mechanisms by which a host of agents kill (or fail to kill) CSCs. The authors characterize three types of CSCs, namely, breast and prostate cancer and mesothelioma cultured as cancer cell spheres in vitro. The analysis of their stemnessis then taken to a new plane by using microarray analysis and the tools of bioinformatics. The tryptophan pathway was the most activated of all pathways whose activation was common to the cancer cells studied suggesting that inhibitors of indoleamine-2,3-dioxygenase (IDO), an enzyme in the tryptophan to N-formyl kynurenin pathway, would be useful for killing CSCs. The authors then develop the principle of mitochondrial targeting by synthesizing a mitochondrially targeted vitamin E succinate [MitoVES] that crosses the mitochondrial inner membrane and acts by targeting the mitochondrial complex II. MitoVES is probably thus far the best characterized agent toxic to CSCs. Two-pronged approach to therapy, therefore, might be desirable.

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Cancer Stem Cells Theories and Practice

ISBN

978-953-307-225-8

Počet stran výsledku

18

Strana od-do

1-442

Počet stran knihy

442

Název nakladatele

InTech

Místo vydání

Rijeka

Kód UT WoS kapitoly

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