Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00431276" target="_blank" >RIV/61388963:_____/14:00431276 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/14:00431276

Výsledek na webu

<a href="http://dx.doi.org/10.1179/1351000213Y.0000000064" target="_blank" >http://dx.doi.org/10.1179/1351000213Y.0000000064</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1179/1351000213Y.0000000064" target="_blank" >10.1179/1351000213Y.0000000064</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy

Popis výsledku v původním jazyce

Malignant mesothelioma (MM) is a fatal neoplastic disease with no therapeutic option. Therefore, the search for novel therapies is of paramount importance. Methods: Since mitochondrial targeting of alpha-tocopheryl succinate (alpha-TOS) by its tagging with triphenylphosphonium enhances its cytotoxic effects to cancer cells, we tested its effect on MM cells and experimental mesotheliomas. Results: Mitochondrially targeted vitamin E succinate (MitoVES) was more efficient in killing MM cells than a-TOS with IC50 lower by up to two orders of magnitude. Mitochondrial association of MitoVES in MM cells was documented using its fluorescently tagged analogue. MitoVES caused apoptosis in MM cells by mitochondrial destabilization, resulting in the loss of mitochondrial membrane potential, generation of reactive oxygen species, and destabilization of respiratory supercomplexes. The role of the mitochondrial complex II in the activity of MitoVES was confirmed by the finding that MM cells with supp

Název v anglickém jazyce

Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy

Popis výsledku anglicky

Malignant mesothelioma (MM) is a fatal neoplastic disease with no therapeutic option. Therefore, the search for novel therapies is of paramount importance. Methods: Since mitochondrial targeting of alpha-tocopheryl succinate (alpha-TOS) by its tagging with triphenylphosphonium enhances its cytotoxic effects to cancer cells, we tested its effect on MM cells and experimental mesotheliomas. Results: Mitochondrially targeted vitamin E succinate (MitoVES) was more efficient in killing MM cells than a-TOS with IC50 lower by up to two orders of magnitude. Mitochondrial association of MitoVES in MM cells was documented using its fluorescently tagged analogue. MitoVES caused apoptosis in MM cells by mitochondrial destabilization, resulting in the loss of mitochondrial membrane potential, generation of reactive oxygen species, and destabilization of respiratory supercomplexes. The role of the mitochondrial complex II in the activity of MitoVES was confirmed by the finding that MM cells with supp

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Redox Report

ISSN

1351-0002

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

16-25

Kód UT WoS článku

000337129600003

EID výsledku v databázi Scopus

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