Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10272121" target="_blank" >RIV/00216208:11310/14:10272121 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/14:00430232

Výsledek na webu

<a href="http://dx.doi.org/10.1111/imm.12219" target="_blank" >http://dx.doi.org/10.1111/imm.12219</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/imm.12219" target="_blank" >10.1111/imm.12219</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells

Popis výsledku v původním jazyce

Regulatory T cells have been well described and the factors regulating their development and function have been identified. Recently, a growing body of evidence has documented the existence of interleukin-10 (IL-10) -producing B cells, which are called regulatory B10 cells. These cells attenuate autoimmune, inflammatory and transplantation reactions, and the main mechanism of their inhibitory action is the production of IL-10. We show that the production of IL-10 by lipopolysaccharide-stimulated B cellsis significantly enhanced by IL-12 and interferon- and negatively regulated by IL-21 and transforming growth factor-. In addition, exogenous IL-10 also inhibits B-cell proliferation and the expression of the IL-10 gene in lipopolysaccharide-stimulated Bcells. The negative autoregulation of IL-10 production is supported by the observation that the inclusion of anti-IL-10 receptor monoclonal antibody enhances IL-10 production and the proliferation of activated B cells. The effects of cyt

Název v anglickém jazyce

Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells

Popis výsledku anglicky

Regulatory T cells have been well described and the factors regulating their development and function have been identified. Recently, a growing body of evidence has documented the existence of interleukin-10 (IL-10) -producing B cells, which are called regulatory B10 cells. These cells attenuate autoimmune, inflammatory and transplantation reactions, and the main mechanism of their inhibitory action is the production of IL-10. We show that the production of IL-10 by lipopolysaccharide-stimulated B cellsis significantly enhanced by IL-12 and interferon- and negatively regulated by IL-21 and transforming growth factor-. In addition, exogenous IL-10 also inhibits B-cell proliferation and the expression of the IL-10 gene in lipopolysaccharide-stimulated Bcells. The negative autoregulation of IL-10 production is supported by the observation that the inclusion of anti-IL-10 receptor monoclonal antibody enhances IL-10 production and the proliferation of activated B cells. The effects of cyt

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunology

ISSN

0019-2805

e-ISSN

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Svazek periodika

141

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

577-586

Kód UT WoS článku

000332474100010

EID výsledku v databázi Scopus

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