Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282734" target="_blank" >RIV/00216208:11310/14:10282734 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/00498254.2013.848310" target="_blank" >http://dx.doi.org/10.3109/00498254.2013.848310</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/00498254.2013.848310" target="_blank" >10.3109/00498254.2013.848310</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

Popis výsledku v původním jazyce

1. Aristolochic acid I (AAI) is the predominant component in plant extract of Aristolochia genus that is involved in development of aristolochic acid nephropathy, Balkan endemic nephropathy and urothelial cancer. The diseases do not develop in all individuals exposed to AAI and patients exhibit different clinical outcomes. Differences in the activities of enzymes catalyzing the metabolism of AAI might be one of the reasons for this individual susceptibility. 2. Understanding which human enzymes are involved in reductive activation of AAI generating AAI-DNA adducts, and/or its detoxication to the O-demethylated metabolite, aristolochic acid Ia (AAIa), is necessary in the assessment of the susceptibility to this compound. 3. This review summarizes the results of the latest studies utilizing genetically engineered mouse models to identify which human and rodent enzymes catalyze the reductive activation of AAI to AAI-DNA adducts and its oxidative detoxication to AAIa in vivo. 4. The use of

Název v anglickém jazyce

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

Popis výsledku anglicky

1. Aristolochic acid I (AAI) is the predominant component in plant extract of Aristolochia genus that is involved in development of aristolochic acid nephropathy, Balkan endemic nephropathy and urothelial cancer. The diseases do not develop in all individuals exposed to AAI and patients exhibit different clinical outcomes. Differences in the activities of enzymes catalyzing the metabolism of AAI might be one of the reasons for this individual susceptibility. 2. Understanding which human enzymes are involved in reductive activation of AAI generating AAI-DNA adducts, and/or its detoxication to the O-demethylated metabolite, aristolochic acid Ia (AAIa), is necessary in the assessment of the susceptibility to this compound. 3. This review summarizes the results of the latest studies utilizing genetically engineered mouse models to identify which human and rodent enzymes catalyze the reductive activation of AAI to AAI-DNA adducts and its oxidative detoxication to AAIa in vivo. 4. The use of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA303%2F09%2F0472" target="_blank" >GA303/09/0472: Studium participace biotransformačních enzymů na vývoji ledvinného selhání a nádorů močových cest vyvolaných aristolochovou kyselinou</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

"Xenobiotica; the fate of foreign compounds in biological systems"

ISSN

0049-8254

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

135-145

Kód UT WoS článku

000332736900005

EID výsledku v databázi Scopus

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