Synthesis of C 3 -symmetric tri(alkylamino) guests and their interaction with cyclodextrins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10286254" target="_blank" >RIV/00216208:11310/15:10286254 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/15:00440000

Výsledek na webu

<a href="http://download.springer.com/static/pdf/597/art%253A10.1007%252Fs10847-014-0443-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs10847-014-0443-1&token2=exp=1450" target="_blank" >http://download.springer.com/static/pdf/597/art%253A10.1007%252Fs10847-014-0443-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs10847-014-0443-1&token2=exp=1450</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10847-014-0443-1" target="_blank" >10.1007/s10847-014-0443-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of C 3 -symmetric tri(alkylamino) guests and their interaction with cyclodextrins

Popis výsledku v původním jazyce

The synthesis of a series of star-shaped C 3 -symmetric amines and their inclusion complexation properties toward ?-, ?-, ?-cyclodextrins and their permethylated derivatives has been described. The star molecules comprise of 1,3,5-trisubstited benzene core and the points formed by (alkylamino)methyl or 4-((alkylamino)methyl)phenyl groups. The modes of host-guest interaction were studied by UV-Vis spectroscopy, ITC, 1H NMR and 2D-NMR (NOESY). It was found that star molecules containing (tert-butylamino)methyl, (adamantan-1-ylamino)methyl, 4-((isopropylamino)methyl)phenyl, 4-((tert-butylamino)methyl)phenyl and protonated 4-((adamantan-1-ylamino)methyl)phenyl points form strong host-guest complexes with ?-cyclodextrin. It was also proved that the largestC 3 -symmetric guest can form complexes with ?-cyclodextrin with stoichiometry 3 which is required for construction of dendrimer supramolecular structures. None of the investigated amines forms a strong complex with permethylated cyclodex

Název v anglickém jazyce

Synthesis of C 3 -symmetric tri(alkylamino) guests and their interaction with cyclodextrins

Popis výsledku anglicky

The synthesis of a series of star-shaped C 3 -symmetric amines and their inclusion complexation properties toward ?-, ?-, ?-cyclodextrins and their permethylated derivatives has been described. The star molecules comprise of 1,3,5-trisubstited benzene core and the points formed by (alkylamino)methyl or 4-((alkylamino)methyl)phenyl groups. The modes of host-guest interaction were studied by UV-Vis spectroscopy, ITC, 1H NMR and 2D-NMR (NOESY). It was found that star molecules containing (tert-butylamino)methyl, (adamantan-1-ylamino)methyl, 4-((isopropylamino)methyl)phenyl, 4-((tert-butylamino)methyl)phenyl and protonated 4-((adamantan-1-ylamino)methyl)phenyl points form strong host-guest complexes with ?-cyclodextrin. It was also proved that the largestC 3 -symmetric guest can form complexes with ?-cyclodextrin with stoichiometry 3 which is required for construction of dendrimer supramolecular structures. None of the investigated amines forms a strong complex with permethylated cyclodex

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-01440S" target="_blank" >GA13-01440S: Chirální supramolekulární polymery založené na derivatizovaných cyklodextrinech jako nové prostředí pro kapilární separační techniky</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inclusion Phenomena and Macrocyclic Chemistry

ISSN

0923-0750

e-ISSN

—

Svazek periodika

81

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

141-152

Kód UT WoS článku

000348415700012

EID výsledku v databázi Scopus

—