Binding properties of novel adamantane-based homotritopic guests

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F15%3A43873282" target="_blank" >RIV/70883521:28110/15:43873282 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Binding properties of novel adamantane-based homotritopic guests

Popis výsledku v původním jazyce

Molecular containers cucurbit[n]urils (CBn) and cyclodextrins (CD) are extensively studied as hosts in supramolecular chemistry due to their ability to form inclusion complexes with derivatives of adamantane, diamantane or ferrocene with outstanding stability. As a part of our ongoing work, we prepared two C3 symmetrical adamantane-based guests G and studied their binding properties towards CB7 and ?-CD in water at 30oC. Using NMR and titration calorimetry, we revealed that guest's binding sites can beeasily occupied by up to three molecules of ?-CD or CB7 to form binary 1:3 aggregates or by all mutual combinations of CB7 and ?-CD units and aggregates G@(CB7,?-CD2) and G@(CB72,?-CD) were detected. Finally, G-bound ?- CD can be rapidly replaced by CB7due to high selectivity of both guests. The ratio of association constants KCB7/K?-CD was calculated from ITC data to be of 4.7.105 and 5.3.103 for trisimidazolium and trisbenzimidazolium guest, respectively. Therefore, we believe that ou

Název v anglickém jazyce

Binding properties of novel adamantane-based homotritopic guests

Popis výsledku anglicky

Molecular containers cucurbit[n]urils (CBn) and cyclodextrins (CD) are extensively studied as hosts in supramolecular chemistry due to their ability to form inclusion complexes with derivatives of adamantane, diamantane or ferrocene with outstanding stability. As a part of our ongoing work, we prepared two C3 symmetrical adamantane-based guests G and studied their binding properties towards CB7 and ?-CD in water at 30oC. Using NMR and titration calorimetry, we revealed that guest's binding sites can beeasily occupied by up to three molecules of ?-CD or CB7 to form binary 1:3 aggregates or by all mutual combinations of CB7 and ?-CD units and aggregates G@(CB7,?-CD2) and G@(CB72,?-CD) were detected. Finally, G-bound ?- CD can be rapidly replaced by CB7due to high selectivity of both guests. The ratio of association constants KCB7/K?-CD was calculated from ITC data to be of 4.7.105 and 5.3.103 for trisimidazolium and trisbenzimidazolium guest, respectively. Therefore, we believe that ou

Druh

O - Ostatní výsledky

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů