Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation: Thermodynamic and Kinetic Studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10294028" target="_blank" >RIV/00216208:11310/15:10294028 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/15:00442242

Výsledek na webu

<a href="http://dx.doi.org/10.1002/chem.201405777" target="_blank" >http://dx.doi.org/10.1002/chem.201405777</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.201405777" target="_blank" >10.1002/chem.201405777</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation: Thermodynamic and Kinetic Studies

Popis výsledku v původním jazyce

Two macrocyclic ligands based on cyclam with trans-disposed N-methyl and N-(4-aminobenzyl) substituents as well as two methylphosphinic (H(2)L1) or methylphosphonic (H(4)L2) acid pendant arms were synthesised and investigated in solution. The ligands form stable complexes with transition metal ions. Both ligands show high thermodynamic selectivity for divalent copper over nickel(II) and zinc(II)K(CuL) is larger than K(Ni/ZnL) by about seven orders of magnitude. Complexation is significantly faster for the phosphonate ligand H(4)L2, probably due to the stronger coordination ability of the more basic phosphonate groups, which efficiently bind the metal ion in an out-of-cage complex and thus accelerate its in-cage binding. The rate of Cu-II complexation by the phosphinate ligand H(2)L1 is comparable to that of cyclam itself and its derivatives with non-coordinating substituents. Acid-assisted decomplexation of the copper(II) complexes is relatively fast ((1/2)=44 and 42s in 1M aq. HClO4 a

Název v anglickém jazyce

Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation: Thermodynamic and Kinetic Studies

Popis výsledku anglicky

Two macrocyclic ligands based on cyclam with trans-disposed N-methyl and N-(4-aminobenzyl) substituents as well as two methylphosphinic (H(2)L1) or methylphosphonic (H(4)L2) acid pendant arms were synthesised and investigated in solution. The ligands form stable complexes with transition metal ions. Both ligands show high thermodynamic selectivity for divalent copper over nickel(II) and zinc(II)K(CuL) is larger than K(Ni/ZnL) by about seven orders of magnitude. Complexation is significantly faster for the phosphonate ligand H(4)L2, probably due to the stronger coordination ability of the more basic phosphonate groups, which efficiently bind the metal ion in an out-of-cage complex and thus accelerate its in-cage binding. The rate of Cu-II complexation by the phosphinate ligand H(2)L1 is comparable to that of cyclam itself and its derivatives with non-coordinating substituents. Acid-assisted decomplexation of the copper(II) complexes is relatively fast ((1/2)=44 and 42s in 1M aq. HClO4 a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

17

Strana od-do

4671-4687

Kód UT WoS článku

000350760000029

EID výsledku v databázi Scopus

2-s2.0-84922571880