Complexes of NOTA-Monoamides with Cu(II) Ions: Structural, Equilibrium, and Kinetic Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10447175" target="_blank" >RIV/00216208:11310/22:10447175 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/22:00125996

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=B04BUjZD63" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=B04BUjZD63</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejic.202200173" target="_blank" >10.1002/ejic.202200173</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Complexes of NOTA-Monoamides with Cu(II) Ions: Structural, Equilibrium, and Kinetic Study

Popis výsledku v původním jazyce

NOTA monoamides are commonly and widely used chelators for the complexation of copper radioisotopes applied in molecular imaging and targeted nuclear therapy. However, information about their coordination behavior remains scarce. In this study, two NOTA-monoamides, N-ethyl (H(2)L1) and N,N-diethyl (H(2)L2), were synthesized as model ligands and tested to probe differences in their coordination behavior between the secondary and tertiary amide pendant arms for potential applications as copper radioisotope carriers. Our results demonstrated that the solid [Cu(L1)] and [Cu(L2)] complex have a distorted octahedral arrangement, similar to structure of the [Cu(Hnota)] complex. As shown by equilibrium data, the ligands have a slightly lower basicity, and thus complexes with divalent metal ions and Li(I) have slightly lower stability constants than those of the parent ligand, H(3)nota. The dissociation constants of the Cu(II), Zn(II) and Ni(II) complexes with H(2)L1 also indicate deprotonation and N-coordination of the secondary amide group at pH&gt;9. Complexation of Cu(II) ions with the title ligands is slower than that with H3nota but still very fast (quantitative binding in &lt;1 s, pH 2, millimolar concentrations), and Cu(II) complexes of both monoamide ligands are more resistant to acid-assisted decomplexation than the Cu(II)-H(3)nota complex. Therefore, our coordination data highlight that NOTA-monoamides are suitable chelators for molecular imaging and nuclear medicine.

Název v anglickém jazyce

Complexes of NOTA-Monoamides with Cu(II) Ions: Structural, Equilibrium, and Kinetic Study

Popis výsledku anglicky

NOTA monoamides are commonly and widely used chelators for the complexation of copper radioisotopes applied in molecular imaging and targeted nuclear therapy. However, information about their coordination behavior remains scarce. In this study, two NOTA-monoamides, N-ethyl (H(2)L1) and N,N-diethyl (H(2)L2), were synthesized as model ligands and tested to probe differences in their coordination behavior between the secondary and tertiary amide pendant arms for potential applications as copper radioisotope carriers. Our results demonstrated that the solid [Cu(L1)] and [Cu(L2)] complex have a distorted octahedral arrangement, similar to structure of the [Cu(Hnota)] complex. As shown by equilibrium data, the ligands have a slightly lower basicity, and thus complexes with divalent metal ions and Li(I) have slightly lower stability constants than those of the parent ligand, H(3)nota. The dissociation constants of the Cu(II), Zn(II) and Ni(II) complexes with H(2)L1 also indicate deprotonation and N-coordination of the secondary amide group at pH&gt;9. Complexation of Cu(II) ions with the title ligands is slower than that with H3nota but still very fast (quantitative binding in &lt;1 s, pH 2, millimolar concentrations), and Cu(II) complexes of both monoamide ligands are more resistant to acid-assisted decomplexation than the Cu(II)-H(3)nota complex. Therefore, our coordination data highlight that NOTA-monoamides are suitable chelators for molecular imaging and nuclear medicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Inorganic Chemistry

ISSN

1434-1948

e-ISSN

1099-0682

Svazek periodika

2022

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

e202200173

Kód UT WoS článku

000807727100001

EID výsledku v databázi Scopus

2-s2.0-85131583434