Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10295343" target="_blank" >RIV/00216208:11310/15:10295343 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2015/838035" target="_blank" >http://dx.doi.org/10.1155/2015/838035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/838035" target="_blank" >10.1155/2015/838035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?

Popis výsledku v původním jazyce

Immunity exhibits extraordinarily high levels of variation. Evolution of the immune system in response to host-pathogen interactions in particular ecological contexts appears to be frequently associated with diversifying selection increasing the geneticvariability. Many studies have documented that immunologically relevant polymorphism observed today may be tens of millions years old and may predate the emergence of present species. This pattern can be explained by the concept of trans-species polymorphism (TSP) predicting the maintenance and sharing of favourable functionally important alleles of immune-related genes between species due to ongoing balancing selection. Despite the generality of this concept explaining the long-lasting adaptive variation inherited from ancestors, current research in TSP has vastly focused only on major histocompatibility complex (MHC). In this review we summarise the evidence available on TSP in human and animal immune genes to reveal that TSP is not a

Název v anglickém jazyce

Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?

Popis výsledku anglicky

Immunity exhibits extraordinarily high levels of variation. Evolution of the immune system in response to host-pathogen interactions in particular ecological contexts appears to be frequently associated with diversifying selection increasing the geneticvariability. Many studies have documented that immunologically relevant polymorphism observed today may be tens of millions years old and may predate the emergence of present species. This pattern can be explained by the concept of trans-species polymorphism (TSP) predicting the maintenance and sharing of favourable functionally important alleles of immune-related genes between species due to ongoing balancing selection. Despite the generality of this concept explaining the long-lasting adaptive variation inherited from ancestors, current research in TSP has vastly focused only on major histocompatibility complex (MHC). In this review we summarise the evidence available on TSP in human and animal immune genes to reveal that TSP is not a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA15-11782S" target="_blank" >GA15-11782S: Biologie stárnutí a senescence: mechanizmy a dynamika u volně žijících ptáků</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Immunology Research

ISSN

2314-8861

e-ISSN

—

Svazek periodika

2015

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000355951500001

EID výsledku v databázi Scopus

2-s2.0-84935859204