Genetics of anti-EHV antibody responses in a horse population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068374" target="_blank" >RIV/00216224:14110/13:00068374 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/13:43872343 RIV/62157124:16810/13:43872343 RIV/62156489:43210/13:00200266

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.rvsc.2013.03.011" target="_blank" >http://dx.doi.org/10.1016/j.rvsc.2013.03.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rvsc.2013.03.011" target="_blank" >10.1016/j.rvsc.2013.03.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genetics of anti-EHV antibody responses in a horse population

Popis výsledku v původním jazyce

Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p&lt;0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populationsby using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status.

Název v anglickém jazyce

Genetics of anti-EHV antibody responses in a horse population

Popis výsledku anglicky

Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p&lt;0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populationsby using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Research in Veterinary Sciences

ISSN

0034-5288

e-ISSN

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Svazek periodika

Vol. 95

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

137-142

Kód UT WoS článku

000320289600022

EID výsledku v databázi Scopus

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