Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059784" target="_blank" >RIV/00216224:14110/12:00059784 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/12:43871607 RIV/62157124:16810/12:43871708 RIV/60460709:41210/12:54885 RIV/62156489:43210/12:00187192

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x" target="_blank" >http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x" target="_blank" >10.1111/j.1399-0039.2011.01827.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Popis výsledku v původním jazyce

Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless ofthe breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely thevariation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzingassociations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.

Název v anglickém jazyce

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Popis výsledku anglicky

Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless ofthe breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely thevariation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzingassociations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tissue Antigens

ISSN

0001-2815

e-ISSN

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Svazek periodika

79

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

247-248

Kód UT WoS článku

000300978800003

EID výsledku v databázi Scopus

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