Molekulární a asociační analýzy u ohroženého plemene: dermatitida u starokladrubských koní

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F07%3A00121242" target="_blank" >RIV/62156489:43210/07:00121242 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Molecular and association analysis in an endangered breed: summer dermatitis in Old Kladruber horses

Popis výsledku v původním jazyce

The autochtonous Old Kladruber horse is considered as an endangered breed. Due to it's isolation and small size, occurrence of various types of diseases may represent a serious threat implicating conservation issues. Summer dermatitis occurring also in the Old Kladruber grey population is an allergic reaction to insect bites, with possible involvement of specific susceptible genotypes. According to manifested clinical signs of summer dermatitis observed over last 8 years, 73 breeding mares were classified as susceptible and resistant, respectively. A combined approach was used to screen the genome for candidate chromosome regions and/or candidate genes. 50 microsatellites and 9 single nucleotide polymorphisms (SNPs) in 5 candidate genes, the lipopolysaccharide (LPS) receptor gene CD14, the toll-like receptor 4 gene TLR4, the gene Ce encoding the IgE heavy chain molecule and the gene FceR1 alpha coding for the alpha subunit of the IgE receptor molecule, were genotyped. Standard Fisher t

Název v anglickém jazyce

Molecular and association analysis in an endangered breed: summer dermatitis in Old Kladruber horses

Popis výsledku anglicky

The autochtonous Old Kladruber horse is considered as an endangered breed. Due to it's isolation and small size, occurrence of various types of diseases may represent a serious threat implicating conservation issues. Summer dermatitis occurring also in the Old Kladruber grey population is an allergic reaction to insect bites, with possible involvement of specific susceptible genotypes. According to manifested clinical signs of summer dermatitis observed over last 8 years, 73 breeding mares were classified as susceptible and resistant, respectively. A combined approach was used to screen the genome for candidate chromosome regions and/or candidate genes. 50 microsatellites and 9 single nucleotide polymorphisms (SNPs) in 5 candidate genes, the lipopolysaccharide (LPS) receptor gene CD14, the toll-like receptor 4 gene TLR4, the gene Ce encoding the IgE heavy chain molecule and the gene FceR1 alpha coding for the alpha subunit of the IgE receptor molecule, were genotyped. Standard Fisher t

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/1G58073" target="_blank" >1G58073: Výzkum a validace genomických metod využitelných v selekci na kvalitu a tržní uplatnění hospodářských zvířat a jejich produktů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů