Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00160935" target="_blank" >RIV/62156489:43210/10:00160935 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses?

Popis výsledku v původním jazyce

Melanoma is a highly prevalent disease in grey horses. The duplication in the syntaxin 17, causing coat colour (greying w ith age) is also associated w ith the formation of skin melanoma. A small proportion of horses do not present melanomas even in higher age. The aim of this study was to identify effects of further candidate genes involved in mechanisms of disease in a small, isolated and partially inbred (FX =0.10) model population of Old Kladruber grey horses. Fifty breeding mares w ere examined byvisual inspection and classified as negative (n=26, age 7-23 years) or positive (n=24, age 7-18 years) for the presence of melanoma. Association analysis w ith 50 microsatellite loci and with 31 polymorphic markers in expressed genes w as performed. Standard two-sided chi-square and/or exact Fisher tests were used to assess associations between polymorphisms detected and variations in the presence of melanoma. Bonferroni corrections for multiple comparisons (81) w ere made. One microsate

Název v anglickém jazyce

Genes for resistance to melanoma: Can we reveal them in Old Kladruber horses?

Popis výsledku anglicky

Melanoma is a highly prevalent disease in grey horses. The duplication in the syntaxin 17, causing coat colour (greying w ith age) is also associated w ith the formation of skin melanoma. A small proportion of horses do not present melanomas even in higher age. The aim of this study was to identify effects of further candidate genes involved in mechanisms of disease in a small, isolated and partially inbred (FX =0.10) model population of Old Kladruber grey horses. Fifty breeding mares w ere examined byvisual inspection and classified as negative (n=26, age 7-23 years) or positive (n=24, age 7-18 years) for the presence of melanoma. Association analysis w ith 50 microsatellite loci and with 31 polymorphic markers in expressed genes w as performed. Standard two-sided chi-square and/or exact Fisher tests were used to assess associations between polymorphisms detected and variations in the presence of melanoma. Bonferroni corrections for multiple comparisons (81) w ere made. One microsate

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/QH92277" target="_blank" >QH92277: Genetická diverzita a její uchování ve vybraných populacích koní v ČR</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů