Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296111" target="_blank" >RIV/00216208:11310/15:10296111 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/cmmi.1606" target="_blank" >http://dx.doi.org/10.1002/cmmi.1606</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cmmi.1606" target="_blank" >10.1002/cmmi.1606</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging

Popis výsledku v původním jazyce

Ligands with geminal bis(phosphonic acid) appended to 1,4,7-triazacyclonone-1,4-diacetic acid fragment through acetamide (NOTAM(BP)) or methylenephosphinate (NO2AP(BP)) spacers designed for Ga-68 were prepared. Ga-III complexation is much faster for ligand with methylenephosphinate spacer than that with acetamide one, in both chemical (high reactant concentrations) and radiolabeling studies with no-carrier-added Ga-68. For both ligands, formation of Ga-III complex was slower than that with NOTA owing tothe strong out-of-cage binding of bis(phosphonate) group. Radiolabeling was efficient and fast only above 60 degrees C and in a narrow acidity region (pH similar to 3). At higher temperature, hydrolysis of amide bond of the carboxamide-bis(phosphonate)conjugate was observed during complexation reaction leading to Ga-NOTA complex. In vitro sorption studies confirmed effective binding of the Ga-68 complexes to hydroxyapatite being comparable with that found for common bis(phosphonate) dr

Název v anglickém jazyce

Gallium(III) complexes of NOTA-bis (phosphonate) conjugates as PET radiotracers for bone imaging

Popis výsledku anglicky

Ligands with geminal bis(phosphonic acid) appended to 1,4,7-triazacyclonone-1,4-diacetic acid fragment through acetamide (NOTAM(BP)) or methylenephosphinate (NO2AP(BP)) spacers designed for Ga-68 were prepared. Ga-III complexation is much faster for ligand with methylenephosphinate spacer than that with acetamide one, in both chemical (high reactant concentrations) and radiolabeling studies with no-carrier-added Ga-68. For both ligands, formation of Ga-III complex was slower than that with NOTA owing tothe strong out-of-cage binding of bis(phosphonate) group. Radiolabeling was efficient and fast only above 60 degrees C and in a narrow acidity region (pH similar to 3). At higher temperature, hydrolysis of amide bond of the carboxamide-bis(phosphonate)conjugate was observed during complexation reaction leading to Ga-NOTA complex. In vitro sorption studies confirmed effective binding of the Ga-68 complexes to hydroxyapatite being comparable with that found for common bis(phosphonate) dr

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-08336S" target="_blank" >GA13-08336S: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Contrast Media and Molecular Imaging

ISSN

1555-4309

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

122-134

Kód UT WoS článku

000353067800004

EID výsledku v databázi Scopus

2-s2.0-84927557001