Formation kinetics of europium(III) complexes of DOTA and its bis(phosphonate) bearing anlogs
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10324081" target="_blank" >RIV/00216208:11310/16:10324081 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.poly.2016.03.039" target="_blank" >http://dx.doi.org/10.1016/j.poly.2016.03.039</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2016.03.039" target="_blank" >10.1016/j.poly.2016.03.039</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Formation kinetics of europium(III) complexes of DOTA and its bis(phosphonate) bearing anlogs
Popis výsledku v původním jazyce
Complexation of Eu(III) ions with H(4)dota and its bis(phosphonate)-bearing analogs, H(8)do3aP(BP) with phosphinate spacer and H(7)dotam(BP) with carboxamide spacer, was studied by UV-Vis spectrophotometry and luminescence life-time measurements. The results show formation of two types of out-of-cage intermediates. The [EuL](oc) intermediate is formed under metal ion excess, whereas [EuL2](oc) intermediate is formed under ligand excess. At room temperature, their conversion to in-cage complex is comparable but the [EuL2](oc) transformation into the in-cage complex is significantly faster at elevated temperatures. Both bis(phosphonate)-bearing ligands show slower complexation rate than H(4)dota. Comparison of reactivity of H(8)do3aP(BP) and H(7)dotam(BP) show important role of the spacer connecting the bis(phosphonate) group with the macrocycle. Presence of phosphinate in H(8)do3aP(BP) leads to significantly faster (3-4 orders of magnitude) complexation than in case of the amide spacer in H(7)dotam(BP). Both bis(phosphonate)-bearing ligands show nonlinear dependence of the complexation rate on concentration of hydroxide anions due to changes in protonation state of the bis(phosphonate) moiety.
Název v anglickém jazyce
Formation kinetics of europium(III) complexes of DOTA and its bis(phosphonate) bearing anlogs
Popis výsledku anglicky
Complexation of Eu(III) ions with H(4)dota and its bis(phosphonate)-bearing analogs, H(8)do3aP(BP) with phosphinate spacer and H(7)dotam(BP) with carboxamide spacer, was studied by UV-Vis spectrophotometry and luminescence life-time measurements. The results show formation of two types of out-of-cage intermediates. The [EuL](oc) intermediate is formed under metal ion excess, whereas [EuL2](oc) intermediate is formed under ligand excess. At room temperature, their conversion to in-cage complex is comparable but the [EuL2](oc) transformation into the in-cage complex is significantly faster at elevated temperatures. Both bis(phosphonate)-bearing ligands show slower complexation rate than H(4)dota. Comparison of reactivity of H(8)do3aP(BP) and H(7)dotam(BP) show important role of the spacer connecting the bis(phosphonate) group with the macrocycle. Presence of phosphinate in H(8)do3aP(BP) leads to significantly faster (3-4 orders of magnitude) complexation than in case of the amide spacer in H(7)dotam(BP). Both bis(phosphonate)-bearing ligands show nonlinear dependence of the complexation rate on concentration of hydroxide anions due to changes in protonation state of the bis(phosphonate) moiety.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CA - Anorganická chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-08336S" target="_blank" >GA13-08336S: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Polyhedron
ISSN
0277-5387
e-ISSN
—
Svazek periodika
111
Číslo periodika v rámci svazku
June
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
7
Strana od-do
143-149
Kód UT WoS článku
000376546500019
EID výsledku v databázi Scopus
2-s2.0-84962422663