DOTA analogues with a phosphinate-iminodiacetate pendant arm: modification of the complex formation rate with a strongly chelating pendant

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10366409" target="_blank" >RIV/00216208:11310/17:10366409 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c7dt01797a" target="_blank" >http://dx.doi.org/10.1039/c7dt01797a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7dt01797a" target="_blank" >10.1039/c7dt01797a</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DOTA analogues with a phosphinate-iminodiacetate pendant arm: modification of the complex formation rate with a strongly chelating pendant

Popis výsledku v původním jazyce

The new ligand H(6)do3aP(ida) combines the macrocyclic DOTA-like cavity and the open-chain iminodiacetate group connected through a coordinating phosphinate spacer. Its acid-base and coordination properties in solution were studied by potentiometry. Thermodynamic coordination characteristics of both chelating units are similar to those reported for H(4)dota and iminodiacetic acid themselves, respectively, so, macrocyclic and iminodiacetate units behave independently. The formation kinetics of the Ce(III)-H(6)do3aP(ida) complex was studied by UV-Vis spectrophotometry. Various out-of-cage intermediates were identified with 1:1, 1:2 and 2:1 ligand-to-metal ratios. The presence of the strongly coordinating iminodiacetate group significantly slows down the metal ion transfer into the macrocyclic cavity and, so, the formation of the in-cage complex is two orders of magnitude slower than that reported for the Ce(III)-H(4)dota system. The kinetic inertness of the [Ce(do3aP(ida))](3-) complex towards acid-assisted dissociation is comparable to that of the [Ce(dota)](-) complex. The coordination modes of the ligand are demonstrated in the solid-state structure of [Cu-4(do3aP(ida))(OH)(H2O)(4)]Cl center dot 7.5H2O.

Název v anglickém jazyce

DOTA analogues with a phosphinate-iminodiacetate pendant arm: modification of the complex formation rate with a strongly chelating pendant

Popis výsledku anglicky

The new ligand H(6)do3aP(ida) combines the macrocyclic DOTA-like cavity and the open-chain iminodiacetate group connected through a coordinating phosphinate spacer. Its acid-base and coordination properties in solution were studied by potentiometry. Thermodynamic coordination characteristics of both chelating units are similar to those reported for H(4)dota and iminodiacetic acid themselves, respectively, so, macrocyclic and iminodiacetate units behave independently. The formation kinetics of the Ce(III)-H(6)do3aP(ida) complex was studied by UV-Vis spectrophotometry. Various out-of-cage intermediates were identified with 1:1, 1:2 and 2:1 ligand-to-metal ratios. The presence of the strongly coordinating iminodiacetate group significantly slows down the metal ion transfer into the macrocyclic cavity and, so, the formation of the in-cage complex is two orders of magnitude slower than that reported for the Ce(III)-H(4)dota system. The kinetic inertness of the [Ce(do3aP(ida))](3-) complex towards acid-assisted dissociation is comparable to that of the [Ce(dota)](-) complex. The coordination modes of the ligand are demonstrated in the solid-state structure of [Cu-4(do3aP(ida))(OH)(H2O)(4)]Cl center dot 7.5H2O.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LTC17067" target="_blank" >LTC17067: Využití NMR relaxačních a difúzních měření pro stanovení dynamiky komplexních molekulárních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dalton Transactions

ISSN

1477-9226

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

31

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

10484-10497

Kód UT WoS článku

000408696100038

EID výsledku v databázi Scopus

2-s2.0-85027099636