Dipeptide interactions with Zn(II)-cyclen artificial model for molecular recognition

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296112" target="_blank" >RIV/00216208:11310/15:10296112 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jmr.2416" target="_blank" >http://dx.doi.org/10.1002/jmr.2416</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jmr.2416" target="_blank" >10.1002/jmr.2416</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dipeptide interactions with Zn(II)-cyclen artificial model for molecular recognition

Popis výsledku v původním jazyce

The Zn(II)-cyclen-dipeptide ternary systems (where cyclen is abbreviated as L and dipeptide is glycylglycine (HL1) or glycyl-(S)-alanine (HL2)) were investigated by potentiometry applying both out-of-cell and direct titrations and by H-1 NMR spectroscopy. Especially, the H-1 NMR study was found to be very efficient to estimate speciation in the systems. The results obtained under full equilibria indicated two main species, [Zn(L)(HL1,2)](2+) and [Zn(L)(L-1,L-2)](+), in both the systems. In the [Zn(L)(HL1,2)](2+) complex, presence of carbonyl-carboxylate chelate was confirmed, and in the [Zn(L)(L-1,L-2)](+) species, the peptide coordination is re-organized to carbonyl-amine chelate or only terminal amino group is coordinated. Equilibrium constants describing [Zn(L)](2+)-dipeptide interaction are relatively low, log K=3.4 for Gly-Gly and 4.1 for Gly-(S)-Ala, respectively. Nevertheless, the values are slightly higher than stability constants for interaction of Zn(II) with the dipeptides (

Název v anglickém jazyce

Dipeptide interactions with Zn(II)-cyclen artificial model for molecular recognition

Popis výsledku anglicky

The Zn(II)-cyclen-dipeptide ternary systems (where cyclen is abbreviated as L and dipeptide is glycylglycine (HL1) or glycyl-(S)-alanine (HL2)) were investigated by potentiometry applying both out-of-cell and direct titrations and by H-1 NMR spectroscopy. Especially, the H-1 NMR study was found to be very efficient to estimate speciation in the systems. The results obtained under full equilibria indicated two main species, [Zn(L)(HL1,2)](2+) and [Zn(L)(L-1,L-2)](+), in both the systems. In the [Zn(L)(HL1,2)](2+) complex, presence of carbonyl-carboxylate chelate was confirmed, and in the [Zn(L)(L-1,L-2)](+) species, the peptide coordination is re-organized to carbonyl-amine chelate or only terminal amino group is coordinated. Equilibrium constants describing [Zn(L)](2+)-dipeptide interaction are relatively low, log K=3.4 for Gly-Gly and 4.1 for Gly-(S)-Ala, respectively. Nevertheless, the values are slightly higher than stability constants for interaction of Zn(II) with the dipeptides (

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Recognition

ISSN

0952-3499

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

211-219

Kód UT WoS článku

000351686600001

EID výsledku v databázi Scopus

2-s2.0-84925409547