Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10313677" target="_blank" >RIV/00216208:11310/15:10313677 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/15:00451351 RIV/00027162:_____/15:#0001343

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.envpol.2015.03.024" target="_blank" >http://dx.doi.org/10.1016/j.envpol.2015.03.024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2015.03.024" target="_blank" >10.1016/j.envpol.2015.03.024</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol

Popis výsledku v původním jazyce

This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (d(ae), mu m) coarse (1 < d(ae) < 10), upper- (0.5 < d(ae) < 1) and lower-accumulation (0.17 < d(ae) < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 studydays and contained 44% of total c-PAHs, while the ultrafine fraction contained only 11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compoun

Název v anglickém jazyce

Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol

Popis výsledku anglicky

This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (d(ae), mu m) coarse (1 < d(ae) < 10), upper- (0.5 < d(ae) < 1) and lower-accumulation (0.17 < d(ae) < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 studydays and contained 44% of total c-PAHs, while the ultrafine fraction contained only 11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compoun

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DI - Znečištění a kontrola vzduchu

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP503%2F12%2FG147" target="_blank" >GBP503/12/G147: Centrum studií toxických vlastností nanočástic</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Pollution

ISSN

0269-7491

e-ISSN

—

Svazek periodika

202

Číslo periodika v rámci svazku

July 2015

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

135-145

Kód UT WoS článku

000354581900017

EID výsledku v databázi Scopus

2-s2.0-84925844096