Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314150" target="_blank" >RIV/00216208:11310/15:10314150 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/15:00448388 RIV/61388980:_____/15:00448388 RIV/00216208:11150/15:10314150 RIV/00023001:_____/15:00059555 RIV/00216208:11120/15:43918744

Výsledek na webu

<a href="http://dx.doi.org/10.1152/ajpgi.00329.2014" target="_blank" >http://dx.doi.org/10.1152/ajpgi.00329.2014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1152/ajpgi.00329.2014" target="_blank" >10.1152/ajpgi.00329.2014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation

Popis výsledku v původním jazyce

Nonalcoholic fatty liver disease is associated with chronic oxidative stress. In our study, we explored the antioxidant effect of antidiabetic metformin on chronic [high-fat diet (HFD)-induced] and acute oxidative stress induced by short-term warm partial ischemia-reperfusion (I/R) or on a combination of both in the liver. Wistar rats were fed a standard diet (SD) or HFD for 10 wk, half of them being administered metformin (150 mg.kg body wtMINUS SIGN 1.dayMINUS SIGN 1). Metformin treatment prevented acute stress-induced necroinflammatory reaction, reduced alanine aminotransferase and aspartate aminotransferase serum activity, and diminished lipoperoxidation. The effect was more pronounced in the HFD than in the SD group. The metformin-treated groups exhibited less severe mitochondrial damage (markers: cytochrome c release, citrate synthase activity, mtDNA copy number, mitochondrial respiration) and apoptosis (caspase 9 and caspase 3 activation). Metformin-treated HFD-fed rats subjecte

Název v anglickém jazyce

Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation

Popis výsledku anglicky

Nonalcoholic fatty liver disease is associated with chronic oxidative stress. In our study, we explored the antioxidant effect of antidiabetic metformin on chronic [high-fat diet (HFD)-induced] and acute oxidative stress induced by short-term warm partial ischemia-reperfusion (I/R) or on a combination of both in the liver. Wistar rats were fed a standard diet (SD) or HFD for 10 wk, half of them being administered metformin (150 mg.kg body wtMINUS SIGN 1.dayMINUS SIGN 1). Metformin treatment prevented acute stress-induced necroinflammatory reaction, reduced alanine aminotransferase and aspartate aminotransferase serum activity, and diminished lipoperoxidation. The effect was more pronounced in the HFD than in the SD group. The metformin-treated groups exhibited less severe mitochondrial damage (markers: cytochrome c release, citrate synthase activity, mtDNA copy number, mitochondrial respiration) and apoptosis (caspase 9 and caspase 3 activation). Metformin-treated HFD-fed rats subjecte

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/LL1204" target="_blank" >LL1204: Genetická analýza mitochondriálního proteomu: Integrace mitochondriální-jaderné epistáze s patofyziologickými fenotypy u potkana</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Physiology - Gastrointestinal and Liver Physiology

ISSN

0193-1857

e-ISSN

—

Svazek periodika

309

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

"G100"-"G111"

Kód UT WoS článku

000357990800005

EID výsledku v databázi Scopus

2-s2.0-84937398039