Natural hybrid of Leishmania infantum/L. donovani: development in Phlebotomus tobbi, P-perniciosus and Lutzomyia longipalpis and comparison with non-hybrid strains differing in tissue tropism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315071" target="_blank" >RIV/00216208:11310/15:10315071 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s13071-015-1217-3" target="_blank" >http://dx.doi.org/10.1186/s13071-015-1217-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13071-015-1217-3" target="_blank" >10.1186/s13071-015-1217-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Natural hybrid of Leishmania infantum/L. donovani: development in Phlebotomus tobbi, P-perniciosus and Lutzomyia longipalpis and comparison with non-hybrid strains differing in tissue tropism

Popis výsledku v původním jazyce

Infection caused by parasites from L. donovani complex can manifest as a serious visceral disease or a self-healing milder cutaneous form. In Cukurova region in Turkey we previously identified a major focus of cutaneous leishmaniasis caused by L. donovani/infantum hybrids (CUK strain) and isolated this parasite from the locally abundant sand fly, Phlebotomus tobbi. Here, we present the first experimental study with P. tobbi. We tested the susceptibility of this species to various Leishmania under laboratory conditions, characterized glycoproteins in the P. tobbi midgut putatively involved in parasite-vector interaction and compared the development of the CUK strain in the sand fly with one other dermotropic and three viscerotropic strains belonging tothe L. donovani complex. High infection rates, heavy parasite loads and late-stage infection with colonization of the stomodeal valve were observed in P. tobbi infected by Leishmania major or L. infantum CUK hybrid. In parallel, lectin bl

Název v anglickém jazyce

Natural hybrid of Leishmania infantum/L. donovani: development in Phlebotomus tobbi, P-perniciosus and Lutzomyia longipalpis and comparison with non-hybrid strains differing in tissue tropism

Popis výsledku anglicky

Infection caused by parasites from L. donovani complex can manifest as a serious visceral disease or a self-healing milder cutaneous form. In Cukurova region in Turkey we previously identified a major focus of cutaneous leishmaniasis caused by L. donovani/infantum hybrids (CUK strain) and isolated this parasite from the locally abundant sand fly, Phlebotomus tobbi. Here, we present the first experimental study with P. tobbi. We tested the susceptibility of this species to various Leishmania under laboratory conditions, characterized glycoproteins in the P. tobbi midgut putatively involved in parasite-vector interaction and compared the development of the CUK strain in the sand fly with one other dermotropic and three viscerotropic strains belonging tothe L. donovani complex. High infection rates, heavy parasite loads and late-stage infection with colonization of the stomodeal valve were observed in P. tobbi infected by Leishmania major or L. infantum CUK hybrid. In parallel, lectin bl

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasites and Vectors

ISSN

1756-3305

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000365331100002

EID výsledku v databázi Scopus

2-s2.0-84947914015