Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10316312" target="_blank" >RIV/00216208:11310/15:10316312 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/15:00444115 RIV/00023001:_____/15:00059349
Výsledek na webu
<a href="http://dx.doi.org/10.1111/apha.12489" target="_blank" >http://dx.doi.org/10.1111/apha.12489</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apha.12489" target="_blank" >10.1111/apha.12489</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
Popis výsledku v původním jazyce
AimIt has been demonstrated that tumour necrosis factor-alpha (TNF-) via its receptor 2 (TNFR2) plays a role in the cardioprotective effects of preconditioning. It is also well known that chronic hypoxia is associated with activation of inflammatory response. With this background, we hypothesized that TNF- signalling may contribute to the improved ischaemic tolerance of chronically hypoxic hearts. MethodsAdult male Wistar rats were kept either at room air (normoxic controls) or at continuous normobarichypoxia (CNH; inspired O-2 fraction 0.1) for 3weeks; subgroups of animals were treated with infliximab (monoclonal antibody against TNF-; 5mgkg(-1), i.p., once a week). Myocardial levels of oxidative stress markers and the expression of selected signalling molecules were analysed. Infarct size (tetrazolium staining) was assessed in open-chest rats subjected to acute coronary artery occlusion/reperfusion. ResultsCNH increased myocardial TNF- level and expression of TNFR2; this response wa
Název v anglickém jazyce
Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
Popis výsledku anglicky
AimIt has been demonstrated that tumour necrosis factor-alpha (TNF-) via its receptor 2 (TNFR2) plays a role in the cardioprotective effects of preconditioning. It is also well known that chronic hypoxia is associated with activation of inflammatory response. With this background, we hypothesized that TNF- signalling may contribute to the improved ischaemic tolerance of chronically hypoxic hearts. MethodsAdult male Wistar rats were kept either at room air (normoxic controls) or at continuous normobarichypoxia (CNH; inspired O-2 fraction 0.1) for 3weeks; subgroups of animals were treated with infliximab (monoclonal antibody against TNF-; 5mgkg(-1), i.p., once a week). Myocardial levels of oxidative stress markers and the expression of selected signalling molecules were analysed. Infarct size (tetrazolium staining) was assessed in open-chest rats subjected to acute coronary artery occlusion/reperfusion. ResultsCNH increased myocardial TNF- level and expression of TNFR2; this response wa
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
—
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Physiologica
ISSN
1748-1708
e-ISSN
—
Svazek periodika
214
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
12
Strana od-do
97-108
Kód UT WoS článku
000353648300010
EID výsledku v databázi Scopus
2-s2.0-84927615290