(eta(6)-Arene) ruthenium complexes with P-coordinated phosphinoferrocene amides bearing extended polar substituents at the amide nitrogen: Synthesis, characterization and cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10323233" target="_blank" >RIV/00216208:11310/16:10323233 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jorganchem.2015.11.009" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2015.11.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2015.11.009" target="_blank" >10.1016/j.jorganchem.2015.11.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

(eta(6)-Arene) ruthenium complexes with P-coordinated phosphinoferrocene amides bearing extended polar substituents at the amide nitrogen: Synthesis, characterization and cytotoxicity

Popis výsledku v původním jazyce

Heterobimetallic Ru-Fe complexes of the general formula [(eta(6)-p-cymene) RuCl2(Ph(2)PfcCONHCH(2)CH(2-)COY-kappa P)], where Y = Me, NH2, NHEt, NHPh, and NMe2, and fc = ferrocene-1,1'-diyl, were synthesized from p-cymene ruthenium dichloride dimer and phosphinoferrocene carboxamide ligands bearing extended urea or acetamido substituents at the amide nitrogen. All the compounds were fully characterized by analytical and spectroscopic methods and, for one representative, also by single-crystal X-ray diffraction analysis. The cytotoxicity of these complexes was examined. The compounds displayed modest antiproliferative activity towards human ovarian cancer cell lines, the exception being a complex with a terminal N-phenylurea moiety which has IC50 values of ca. 20 microM.

Název v anglickém jazyce

(eta(6)-Arene) ruthenium complexes with P-coordinated phosphinoferrocene amides bearing extended polar substituents at the amide nitrogen: Synthesis, characterization and cytotoxicity

Popis výsledku anglicky

Heterobimetallic Ru-Fe complexes of the general formula [(eta(6)-p-cymene) RuCl2(Ph(2)PfcCONHCH(2)CH(2-)COY-kappa P)], where Y = Me, NH2, NHEt, NHPh, and NMe2, and fc = ferrocene-1,1'-diyl, were synthesized from p-cymene ruthenium dichloride dimer and phosphinoferrocene carboxamide ligands bearing extended urea or acetamido substituents at the amide nitrogen. All the compounds were fully characterized by analytical and spectroscopic methods and, for one representative, also by single-crystal X-ray diffraction analysis. The cytotoxicity of these complexes was examined. The compounds displayed modest antiproliferative activity towards human ovarian cancer cell lines, the exception being a complex with a terminal N-phenylurea moiety which has IC50 values of ca. 20 microM.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-08890S" target="_blank" >GA13-08890S: Polární ferrocenové amidofosfinové ligandy pro katalytické aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Organometallic Chemistry

ISSN

0022-328X

e-ISSN

—

Svazek periodika

802

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

21-26

Kód UT WoS článku

000366928900004

EID výsledku v databázi Scopus

2-s2.0-84948434158