Identification of STAT3 and STAT5 Proteins in the Rat Suprachiasmatic Nucleus and the Day/Night Difference in Astrocytic STAT3 Phosphorylation in Response to Lipopolysaccharide
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10333271" target="_blank" >RIV/00216208:11310/16:10333271 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1002/jnr.23673" target="_blank" >http://dx.doi.org/10.1002/jnr.23673</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jnr.23673" target="_blank" >10.1002/jnr.23673</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Identification of STAT3 and STAT5 Proteins in the Rat Suprachiasmatic Nucleus and the Day/Night Difference in Astrocytic STAT3 Phosphorylation in Response to Lipopolysaccharide
Popis výsledku v původním jazyce
Signal transducers and activators of transcription (STAT) proteins regulate many aspects of cellular physiology from growth and differentiations to immune responses. Using immunohistochemistry, we show the daily rhythm of STAT3 protein in the rat suprachiasmatic nucleus (SCN), with low but significant amplitude peaking in the morning. We also reveal the strong expression of STAT5A in astrocytes of the SCN and the STAT5B signal in nonastrocytic cells. Administration of lipopolysaccharide (LPS) acutely induced phosphorylation of STAT3 on Tyr705 during both the day and the night and induced phosphorylation on Ser727 but only after the daytime application. The LPS-induced phospho-STAT3 (Tyr705) remained elevated for 24 hr after the daytime application but declined within 8 hr when LPS was applied at night. (C) 2015 Wiley Periodicals, Inc.
Název v anglickém jazyce
Identification of STAT3 and STAT5 Proteins in the Rat Suprachiasmatic Nucleus and the Day/Night Difference in Astrocytic STAT3 Phosphorylation in Response to Lipopolysaccharide
Popis výsledku anglicky
Signal transducers and activators of transcription (STAT) proteins regulate many aspects of cellular physiology from growth and differentiations to immune responses. Using immunohistochemistry, we show the daily rhythm of STAT3 protein in the rat suprachiasmatic nucleus (SCN), with low but significant amplitude peaking in the morning. We also reveal the strong expression of STAT5A in astrocytes of the SCN and the STAT5B signal in nonastrocytic cells. Administration of lipopolysaccharide (LPS) acutely induced phosphorylation of STAT3 on Tyr705 during both the day and the night and induced phosphorylation on Ser727 but only after the daytime application. The LPS-induced phospho-STAT3 (Tyr705) remained elevated for 24 hr after the daytime application but declined within 8 hr when LPS was applied at night. (C) 2015 Wiley Periodicals, Inc.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP303%2F12%2F1137" target="_blank" >GAP303/12/1137: Úloha proteinů STAT v cirkadiánním systému potkana</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Neuroscience Research
ISSN
0360-4012
e-ISSN
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Svazek periodika
94
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
99-108
Kód UT WoS článku
000363749400009
EID výsledku v databázi Scopus
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