PHYSICOCHEMICAL INVESTIGATION OF STABILITY OF APOFERRITIN WITH ENCAPSULATED DOXORUBICIN

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10372820" target="_blank" >RIV/00216208:11310/16:10372820 - isvavai.cz</a>

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RIV/62156489:43210/16:43910231 RIV/00216305:26620/16:PU122771

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

PHYSICOCHEMICAL INVESTIGATION OF STABILITY OF APOFERRITIN WITH ENCAPSULATED DOXORUBICIN

Popis výsledku v původním jazyce

The many negative side effects of drugs used for treatment of highly diverse diseases, such as cancer, lead in recent years to the development of ways how to target the drug selectively to the diseased tissue while avoiding the healthy cells. Nanocarriers, made from various materials, can serve as a suitable platform for this targeted drug delivery. Herein, we evaluate the long-term stability of nanocarrier based on ubiquitous protein apoferritin with encapsulated doxorubicin. Various properties of the nanocarrier were observed over the course of 12 weeks while stored at various temperatures, such as premature drug release, optical properties of the encapsulated drug, nanocarrier size and surface zeta potential. The nanocarrier showed very good stability for up to 12 weeks with the best results observed with nanocarrier prepared in water and stored at dark at 4 degrees C.

Název v anglickém jazyce

PHYSICOCHEMICAL INVESTIGATION OF STABILITY OF APOFERRITIN WITH ENCAPSULATED DOXORUBICIN

Popis výsledku anglicky

The many negative side effects of drugs used for treatment of highly diverse diseases, such as cancer, lead in recent years to the development of ways how to target the drug selectively to the diseased tissue while avoiding the healthy cells. Nanocarriers, made from various materials, can serve as a suitable platform for this targeted drug delivery. Herein, we evaluate the long-term stability of nanocarrier based on ubiquitous protein apoferritin with encapsulated doxorubicin. Various properties of the nanocarrier were observed over the course of 12 weeks while stored at various temperatures, such as premature drug release, optical properties of the encapsulated drug, nanocarrier size and surface zeta potential. The nanocarrier showed very good stability for up to 12 weeks with the best results observed with nanocarrier prepared in water and stored at dark at 4 degrees C.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA14-18344S" target="_blank" >GA14-18344S: Vývoj nanočástic obsahujících cytostatika a enzymy pro zlepšení chemotherapie lidských neuroblastomů a studium mechanismu jejich působení</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS OF INTERNATIONAL PHD STUDENTS CONFERENCE, (MENDELNET 2016)

ISBN

978-80-7509-443-8

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

6

Strana od-do

966-971

Název nakladatele

MENDEL UNIV BRNO, FAC AGRONOMY

Místo vydání

BRNO

Místo konání akce

Mendel Univ Brno, Fac AgriSciences, Brno

Datum konání akce

9. 11. 2016

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000392968500173